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Methods of synthesizing hydroxyapatite powders and bulk materials

  • US 5,858,318 A
  • Filed: 11/27/1996
  • Issued: 01/12/1999
  • Est. Priority Date: 11/27/1996
  • Status: Expired due to Term
First Claim
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1. A method for synthesizing non-porous hydroxyapatite materials of controlled morphology comprising:

  • (a) preparing a hydroxyapatite slurry;

    (b) adjusting the concentration, viscosity and pH values of the hydroxyapatite slurry to a concentration ranging from about 0 volume fraction to about 0.25 volume fraction and a viscosity ranging from about 0.5 cst to about 50 cst;

    (c) spray drying the hydroxyapatite slurry to form granules using atomization pressure ranging from about 1 kg/cm2 to about 5 kg/cm2, and optionally, employing a heated coaxial air;

    (d) heating the spray-dried granules to a temperature ranging from about 400°

    C. to about 500°

    C. to remove residual water;

    (e) collecting the hydroxyapatite granules of step (d) wherein the concentration, viscosity and pH values of the hydroxyapatite slurry and the atomization pressure are varied to produce non-porous granules of 8 μ

    m or less and a controlled morphology selected from the group consisting of hollow spheres and doughnuts; and

    (f) sintering the collected granules from step (e) to form ceramic hydroxyapatite hollow spheres and doughnuts.

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