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Poly-substituted-phenyl-oligoribo nucleotides having enhanced stability and membrane permeability and methods of use

  • US 5,858,988 A
  • Filed: 02/22/1996
  • Issued: 01/12/1999
  • Est. Priority Date: 02/24/1993
  • Status: Expired due to Fees
First Claim
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1. An antisense oligoribonucleotide conjugated at the 2'"'"'-O position with a substituted phenyl group to produce a derivatized compound of the following general structure:

  • ##STR18## wherein R1, R2, R3, R4, and R5 are independently H, NO2, halide, linear or branched alkyl, linear or branched acyl, linear or branched alkylene, linear or branched O-alkyl, linear or branched amido, linear or branched S-alkyl, mono or disubstituted amine, linear or branched thioamido, phosphorothioate, or phosphothioate.

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