Prepolymers of absorbable polyoxaesters
First Claim
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1. A prepolymer comprising an aliphatic polyoxaester having a first divalent repeating unit of formula I:
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space="preserve" listing-type="equation"> O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1) (R.sub.2)--C(O)--!tm Iand a second repeating unit selected from the group of formulas consisting of;
##STR6## and combinations thereof, wherein R1 and R2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms;
R3 is an alkylene unit containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula;
space="preserve" listing-type="equation">-- (CH.sub.2).sub.C --O--!.sub.D --(CH.sub.2).sub.E -- IVwherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer from 2 to 12;
R4 is an alkylene unit containing from 2 to 8 carbon atoms;
A is an integer in the range of from 1 to 2,000;
R5 is selected from the group consisting of --C(R6)(R7)--, --(CH2)3 --O--, --CH2 --CH2 --O--CH2 --, --CR8 H--CH2 --, --(CH2)5 --, --(CH2)F --O--C(O)-- and --(CH2)F --C(O)--CH2 --;
R6 and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms;
R8 is hydrogen or methyl;
F is an integer in the range of from 2 to 6;
B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000;
P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000;
G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and
L is an integer from about 1 to about 200;
wherein the polyoxaester is covalently linked to a polymerizable region.
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Abstract
The present invention describes a prepolymer of an aliphatic polyoxaester having a polymerizable end group that may be used to produce hydrogels, surgical devices such as sutures, sutures with attached needles, molded devices, and the like.
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Citations
14 Claims
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1. A prepolymer comprising an aliphatic polyoxaester having a first divalent repeating unit of formula I:
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space="preserve" listing-type="equation"> O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1) (R.sub.2)--C(O)--!tm Iand a second repeating unit selected from the group of formulas consisting of;
##STR6## and combinations thereof, wherein R1 and R2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms;
R3 is an alkylene unit containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula;
space="preserve" listing-type="equation">-- (CH.sub.2).sub.C --O--!.sub.D --(CH.sub.2).sub.E -- IVwherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer from 2 to 12;
R4 is an alkylene unit containing from 2 to 8 carbon atoms;
A is an integer in the range of from 1 to 2,000;
R5 is selected from the group consisting of --C(R6)(R7)--, --(CH2)3 --O--, --CH2 --CH2 --O--CH2 --, --CR8 H--CH2 --, --(CH2)5 --, --(CH2)F --O--C(O)-- and --(CH2)F --C(O)--CH2 --;
R6 and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms;
R8 is hydrogen or methyl;
F is an integer in the range of from 2 to 6;
B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000;
P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000;
G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and
L is an integer from about 1 to about 200;
wherein the polyoxaester is covalently linked to a polymerizable region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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Specification