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Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes

  • US 5,859,228 A
  • Filed: 10/25/1996
  • Issued: 01/12/1999
  • Est. Priority Date: 05/04/1995
  • Status: Expired due to Term
First Claim
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1. A method for the preparation of a Complex comprised of a vascular endothelial growth factor (VEGF) Nucleic Acid Ligand and a Lipophilic Compound, said method comprising:

  • a) contacting the Candidate Mixture with VEGF, wherein Nucleic Acids having an increased affinity to VEGF relative to the Candidate Mixture may be partitioned from the remainder of the Candidate Mixture;

    b) partitioning the increased affinity VEGF Nucleic Acids from the remainder of the Candidate Mixture;

    c) amplifying the increased affinity VEGF Nuclcic Acids to yield a ligand-enriched mixture of Nucleic Acids; and

    d) covalently linking said identified VEGF Nucleic Acid Ligand with a Lipophilic Compound.

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