Method and device for mechanical imaging of breast
First Claim
1. The method of identifying a region within a tissue portion of a human breast having a different elasticity than the surrounding tissue, said method comprising the steps of:
- causing a deformation of an examined tissue portion of said breast;
detecting temporal and spatial changes in a pressure pattern caused by said deformation measured on the surface of the examined tissue portion;
defining a model of the tissue portion with homogenous tissue and with boundary conditions corresponding to the examined tissue portion;
evaluation respective temporal and spatial changes in the pressure pattern for said defined model under the same loading conditions as in the detecting step;
adjusting iteratively said defined model by varying a spatial distribution of modulus of elasticity in the model to minimize the difference between said temporal and spatial changes in the pressure pattern obtained in the detecting step and the respective temporal and spatial changes in the pressure pattern evaluated for the adjusted model, thereby obtaining spatial distribution of elasticity modulus in the tissue portion; and
visualizing and displaying spatial distribution of modulus of elasticity in said adjusted model of the examined tissue portion for indicating the presence and location of a differing elasticity region of tissue within the examined tissue portion.
8 Assignments
0 Petitions
Accused Products
Abstract
A method and devices in accordance with the present invention enable detecting regions of breast tissue having modulus of elasticity different from that of surrounding glandular tissue using a pressure sensing array. Detection of breast tumors is based on analyzing features of the stress pattern on the surface of an examined tissue that appear as a deviation from a stress pattern for a relatively homogeneous normal tissue. In one embodiment of the invention, a pressure sensor array, data acquisition circuit, and a microprocessor are mounted in a hand held pad. Detection of nodules is achieved by analyzing the dynamic and spatial features of the pressure pattern while the probe pressed to the breast is periodically moved transversely to the ribs. The ribs play a role as an amplifier of the measured effect. The device will be able to objectively detect the presence of lumps in a breast and provide a warning signal. Another embodiment of the invention is a clinical device for imaging the mechanical structure of the examined breast and diagnosing diseases accompanied by changes in the elasticity of breast tissue. This embodiment is made up of an electronically controlled mechanical scanning unit incorporated into a patient support bed. The mechanical scanning unit includes a compression mechanism and positioning system, a local pressure source located opposite a pressure sensor array, and electronic control and interface circuitry. The local pressure source is either a roller moving over the examined breast, or in another embodiment, an indenter which can be moved in all three dimensions and be controlled either automatically by a computer or manually by a mouse. In yet another embodiment, the mechanical scanning system serves as a biopsy guidance means and determines target lesions in the breast to be reached by a biopsy gun or an aspiration needle.
-
Citations
8 Claims
-
1. The method of identifying a region within a tissue portion of a human breast having a different elasticity than the surrounding tissue, said method comprising the steps of:
-
causing a deformation of an examined tissue portion of said breast; detecting temporal and spatial changes in a pressure pattern caused by said deformation measured on the surface of the examined tissue portion; defining a model of the tissue portion with homogenous tissue and with boundary conditions corresponding to the examined tissue portion; evaluation respective temporal and spatial changes in the pressure pattern for said defined model under the same loading conditions as in the detecting step; adjusting iteratively said defined model by varying a spatial distribution of modulus of elasticity in the model to minimize the difference between said temporal and spatial changes in the pressure pattern obtained in the detecting step and the respective temporal and spatial changes in the pressure pattern evaluated for the adjusted model, thereby obtaining spatial distribution of elasticity modulus in the tissue portion; and visualizing and displaying spatial distribution of modulus of elasticity in said adjusted model of the examined tissue portion for indicating the presence and location of a differing elasticity region of tissue within the examined tissue portion.
-
-
2. The method of identifying a region within a tissue portion of a human breast having a different elasticity than the surrounding tissue, said method comprising the steps of:
-
causing a first deformation of an examined tissue portion of said breast; causing an additional local second deformation of the surface of the examined tissue portion, the second deformation occurring over a substantially smaller area than the region of the first deformation; detecting temporal and spatial changes in a pressure pattern caused by said first deformation and said local second deformation measured on the surface of the examined tissue portion; defining a model of the tissue portion with homogenous tissue and with boundary conditions corresponding to the examined tissue portion; evaluating respective temporal and spatial changes in the pressure pattern for said defined model under the same loading conditions as in the detecting step; and comparing the temporal and spatial changes in the pressure pattern obtained in the detecting step and the temporal and spatial changes in the pressure pattern evaluated in the evaluating step, the deference indicating the presence and location of a differing elasticity region of tissue within the examined tissue portion. - View Dependent Claims (3, 4, 5, 6)
-
-
7. A device for identifying a region within an examined tissue portion of a human breast having a different elasticity than the surrounding tissue, said device comprising:
-
means for causing a first deformation of the examined tissue portion, thereby causing stress and strain in the examined tissue portion; means for detecting temporal and spatial changes in the pressure pattern measured on the surface of the examined tissue portion; means for defining a model of the tissue portion with homogeneous tissue and with boundary conditions corresponding to the examined tissue portion; means for evaluating respective temporal and spatial changes in the pressure pattern for said defined model under the same loading conditions as in the detecting step; means for comparing the temporal and spatial changes in the pressure pattern obtained in the detecting step and the temporal and spatial changes in the pressure pattern evaluated in the evaluating step, the difference indicating the presence and location of a differing elasticity region of tissue within the tissue portion; means for adjusting iteratively said defined model by varying a spatial distribution of modulus of elasticity in the model to minimize the difference between said temporal and spatial changes in the pressure pattern obtained in the detecting step and the respective temporal and spatial changes in the pressure pattern evaluated for the adjusting model, thereby and obtaining spatial distribution of elasticity modulus in the tissue portion; and means for visualizing and displaying spatial distribution of modulus of elasticity in said adjusted model of the examined tissue portion to indicate the presence and location of a differing elasticity region of tissue within the examined tissue portion. - View Dependent Claims (8)
-
Specification