Multipathway electronically-controlled drug delivery system
First Claim
1. A multipathway automatic and on-demand drug delivery system for multiple administrations at selectable dispensing times of at least one type of drug, said system comprising:
- a plurality of drug storage and delivery means wherein each has at least one drug storage reservoir and an actuable drug delivery system which receives a signal causing the drug delivery system to eject the at least one type of drug from the at least one drug storage reservoir, said plurality of drug storage and delivery means comprising;
a plurality of generally hollow dual-chambered delivery pods having an enclosed top face and bottom face, and where the chambers are generally arranged as an upper chamber and a lower chamber;
the upper chamber which functions as a propellant chamber having a ceiling a combustible propellant charge in the propellant chamber which is proximate to the ceiling;
an ignition means for igniting the combustible propellant charge;
a piston located between the propellant chamber and the lower chamber, wherein said piston has generally flat top and bottom faces;
the lower chamber functioning as a drug reservoir chamber situated beneath the piston, having the piston as a ceiling, a puncturable membrane associated with said drug reservoir chamber; and
an outlet port beneath the puncturable floor membrane and extending through an aperture in the bottom face of the drug reservoir chamber to enable ejection of the drug therefrom;
a drug storage and delivery module which holds the plurality of drug storage and delivery means in position until ejection of the at least one type of drug therefrom;
a securing means for coupling the drug storage and delivery module to a patient; and
a control means which is coupled to the drug storage and delivery module and which transmits the signal causing the drug delivery system to eject the at least one type of drug at the selectable dispensing times.
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Accused Products
Abstract
A low-profile multipathway automatic drug delivery system utilizing a battery powered control pad coupled to a disposable drug storage and delivery system and strapped to a patient'"'"'s limb or torso. A preprogrammed or on-demand drug administration sequence is input to the control pad. When a drug is to be administered, the control pad ignites a high energy density propellant charge in the drug delivery system. Expanding propellant gas exerts pressure on a drug in a second chamber and forces it from the storage reservoir. Depending upon the type of drug delivery system required for the drug being administered, the propellant will either: (i) force a hypodermic needle into a patient'"'"'s muscle tissue, propel the drug in the storage container into the needle embedded in the patient, and withdraw the needle; (ii) force the drug from the storage container through a jet nozzle where the drug is injected into subcutaneous tissue; (iii) force the drug from the storage container into a patch for passive transdermal delivery; (iv) force the drug into a patch for iontophoretic transdermal diffusion; or (v) force together two drugs stored separately that are unstable when mixed, and then administer them through one of the methods described in steps (i) to (iv).
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Citations
42 Claims
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1. A multipathway automatic and on-demand drug delivery system for multiple administrations at selectable dispensing times of at least one type of drug, said system comprising:
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a plurality of drug storage and delivery means wherein each has at least one drug storage reservoir and an actuable drug delivery system which receives a signal causing the drug delivery system to eject the at least one type of drug from the at least one drug storage reservoir, said plurality of drug storage and delivery means comprising; a plurality of generally hollow dual-chambered delivery pods having an enclosed top face and bottom face, and where the chambers are generally arranged as an upper chamber and a lower chamber; the upper chamber which functions as a propellant chamber having a ceiling a combustible propellant charge in the propellant chamber which is proximate to the ceiling; an ignition means for igniting the combustible propellant charge; a piston located between the propellant chamber and the lower chamber, wherein said piston has generally flat top and bottom faces; the lower chamber functioning as a drug reservoir chamber situated beneath the piston, having the piston as a ceiling, a puncturable membrane associated with said drug reservoir chamber; and an outlet port beneath the puncturable floor membrane and extending through an aperture in the bottom face of the drug reservoir chamber to enable ejection of the drug therefrom; a drug storage and delivery module which holds the plurality of drug storage and delivery means in position until ejection of the at least one type of drug therefrom; a securing means for coupling the drug storage and delivery module to a patient; and a control means which is coupled to the drug storage and delivery module and which transmits the signal causing the drug delivery system to eject the at least one type of drug at the selectable dispensing times. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 37, 38, 39, 40, 41)
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25. A multipathway automatic and on-demand drug delivery system for multiple administrations at selectable dispensing times of at least one type of drug, said system comprising:
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a plurality of drug storage and delivery means wherein each has at least one drug storage reservoir and an actuable drug delivery system which receives a signal causing the drug delivery system to eject the at least one type of drug from the at least one drug storage reservoir, said plurality of drug storage and delivery means comprising; an inner pod cylinder sealed at both ends and having a rigid cylindrical housing, wherein said inner pod comprises; (i) a top lid has a lip extending horizontally from the side of said lid, (ii) a first gas entry port in a wall, (iii) a bottom lid from which a needle extends perpendicularly through an aperture, and (iv) a collapsible membrane anchored to the bottom lid and surrounding a needle inlet port that extends into the bottom lid, and wherein a drug is stored within said membrane; an outer pod cylinder within which the inner pod cylinder fits in sliding engagement, wherein said outer pod comprises; (i) an uppermost lid with a single gas vent, (ii) a flex circuit with a first and a second propellant charge thereon which is fixed to the bottom of said uppermost lid, (iii) a second lid with said single gas vent, (iv) a first propellant charge aperture positioned so as to encircle the first propellant charge that extends downward through said aperture, (v) a second propellant charge aperture positioned so as to encircle the second propellant charge that extends downward through said aperture, (vi) an L-shaped plug positioned to initially seal the single gas vent and to catch the horizontal lip of the inner pod when the inner pod descends a distance down through the outer pod, (vii) a recessed groove with a ledge on an outer pod inner wall to hold the L-shaped plug and allow vertical movement of the inner pod horizontal lip and the plug until said lip and said plug reach the ledge, (viii) a propellant gas passage through the outer pod inner wall that enables first propellant charge gas to enter, flow through said passage and enter the inner pod through the first gas entry port, (ix) a second bottom lid which seals the outer pod, with an aperture through said lid for the needle, (x) a needle guard that surrounds the injectable end of the needle, and (xi) a second propellant gas passage leading from the second propellant gas charge to flow underneath the inner pod; a drug storage and delivery module which holds the plurality of drug storage and delivery means in position until ejection of the at least one type of drug therefrom; a securing means for coupling the drug storage and delivery module to a patient; and a control means which is coupled to the drug storage and delivery module and which transmits the signal causing the drug delivery system to eject the at least one type of drug at the selectable dispensing times. - View Dependent Claims (26)
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27. A multipathway automatic and on-demand drug delivery system for multiple administrations at selectable dispensing times of at least one type of drug, said system comprising:
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a plurality of drug storage and delivery means wherein each has at least one drug storage reservoir and an actuable drug delivery system which receives a signal causing the drug delivery system to eject the at least one type of drug from the at least one drug storage reservoir, said plurality of drug storage and delivery means comprising; at least one straight and hollow cylindrical housing having an exterior and interior back end and front end; a cylindrical hypodermic needle delivery pod which moves in sliding engagement within the length of the housing, and which is distally disposed from the front end of the housing before actuation; means for injecting a hypodermic needle, which is coupled to the hypodermic needle delivery pod, through an aperture in the housing and into a patient, comprising; a first pair of ignition leads coupled to the control means and which extend through the exterior and partially into the interior of the back end of the housing; and ignition means disposed within and coupled to the two ignition leads in the interior of the housing for igniting a combustible propellant charge, the combustible propellant charge surrounding the ignition means and which will ignite responsive to the signal applied to the first pair of ignition leads, thereby forcing the hypodermic needle delivery pod toward the front end of the housing, and causing the hypodermic needle to penetrate a patient'"'"'s skin; means for extracting the hypodermic needle from the patient after drug injection, a drug storage and delivery module which holds the plurality of drug storage and delivery means in position until ejection of the at least one type of drug therefrom; a securing means for coupling the drug storage and delivery module to a patient; and a control means which is coupled to the drug storage and delivery module and which transmits the signal causing the drug delivery system to eject the at least one type of drug at the selectable dispensing times. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36)
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42. A multipathway automatic and on-demand drug delivery system for multiple administrations at selectable dispensing times of at least one type of drug, said system comprising:
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a plurality of drug storage and delivery means wherein each has at least one drug storage reservoir and an actuable drug delivery system which receives a signal causing the drug delivery system to eject the at least one type of drug from the at least one drug storage reservoir, said plurality of drug storage and delivery means comprising; a first chamber for holding a first drug, wherein the first chamber is compressible to thereby eject a mixed drug from an ejection end thereof; a second chamber for holding a second drug, wherein the second chamber is compressible to thereby eject the second drug therefrom; a one-way port coupling the first chamber and the second chamber, whereby the second drug is introduced into the first chamber for mixing with the first drug to produce the mixed drug; a first propellant charge for compressing the second chamber to force the second drug into the first chamber via the one-way port; and a second propellant charge for compressing the first chamber to thereby eject the mixed drug therefrom via the ejection ends a drug storage and delivery module which holds the plurality of drug storage and delivery means in position until ejection of the at least one type of drug therefrom; a securing means for coupling the drug storage and delivery module to a patient; and a control means which is coupled to the drug storage and delivery module and which transmits the signal causing the drug delivery system to eject the at least one type of drug at the selectable dispensing times.
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Specification