Medical device having a biocompatible coating and oxidation method of coupling therefor

• US 5,861,032 A
• Filed: 01/31/1996
• Issued: 01/19/1999
• Est. Priority Date: 01/31/1996
• Status: Expired due to Fees

• Current Assignee: Surface Genesis, Inc.
• Original Assignee: Surface Genesis, Inc.
• Inventors: Subramaniam, Raj
• Primary Examiner(s): Yu, Mickey
• Assistant Examiner(s): Black, John M.
• Application Number:
  US08/594,872
• Time in Patent Office: 1,084 Days
• Field of Search: 623/1, 623/16, 623/66
• US Class Current: 424/423
• CPC Class Codes: A61F 2/12 Mammary prostheses and implants
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61L 27/042 Iron or iron alloys
• CPC Class Codes: A61L 27/06 Titanium or titanium alloys
• CPC Class Codes: A61L 27/22 Polypeptides or derivatives thereof , e.g. degradation products
• CPC Class Codes: A61L 27/227 Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
• CPC Class Codes: A61L 27/28 Materials for coating prostheses
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 31/043 Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61L 31/047 Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
• CPC Class Codes: A61L 31/08 Materials for coatings
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08L 89/00 Compositions of proteins; Compositions of derivatives thereof foodstuff preparations A23J3/00

Abstract

A medical device for implantation in the tissue of a human body having a biocompatible coating thereon including a foreign body formed of a material which is substantially biocompatible with the tissue of the human body. The foreign body has a surface adapted to come in contact with the tissue of the human body and is capable of being oxidized. An organic linker is carried on the surface and forms an oxidative coupling with the surface. A bioactive agent is bonded to the organic linker by a chemical reaction or photochemical function.

Claims

1. A medical device for implantation in the tissue of a human body having a biocompatible coating thereon, said device comprising a foreign body formed of a material which is substantially biocompatible with the tissue of the human body, said foreign body having a surface adapted to come in contact with the tissue of the human body, said surface being capable of being oxidized, said coating including an organic linker bonded directly to said surface and forming an oxidative coupling with said surface, and a bioactive agent bonded to the organic linker by a reactive function.

2. A device as in claim 1 wherein said organic linker is selected from the group consisting of cystines, organic peroxides, organic sulfone, sulfoxide and sulfonic acids.

3. A device as in claim 2 wherein said bioactive agent is selected from the group consisting of growth promoters, anti-thrombogenic agents, steroids, antibiotics, hormones and cytokines.

4. A device as in claim 3 wherein said bioactive agent includes a peptide.

5. A device as in claim 4 wherein said peptide is in a form of 15 amino acid long cell binding peptide.

6. A device as in claim 1 wherein said reactive function is capable of undergoing a reaction selected from the group consisting of a condensation reaction, oxidative reaction, exchange reaction and substitution reaction.

7. A device as in claim 1 wherein said device is formed of a metal which is substantially biocompatible with the human body.

8. A device as in claim 7 wherein said metal is selected from the group consisting of stainless steel, titanium, and alloys of titanium.

9. A device as in claim 1 wherein said device is a dental post.

10. A device as in claim 1 wherein said device is a stent.

11. A device as in claim 1 wherein said material is formed of plastic.

12. A device as in claim 1 wherein said device is a breast implant.