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Methods for identifying compounds that modulate mammalian tub protein activity

  • US 5,861,239 A
  • Filed: 09/02/1997
  • Issued: 01/19/1999
  • Est. Priority Date: 04/12/1996
  • Status: Expired due to Fees
First Claim
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1. A method for identifying compounds that modulate tub protein activity, comprising:

  • (a) contacting a cell expressing a tub protein, an extract thereof, or an isolated tub protein, in the presence or absence of a test compound with a SH2 containing peptide,(b) determining whether the test compound alters the interaction of the tub protein with the SH2 containing peptide, and(c) selecting the test compound that alters the interaction of the tub protein with the SH2 containing peptidewherein the tub protein comprises;

    (i) the amino acid sequence shown in SEQ ID NO;

    2,(ii) amino acid residues 1-133 shown in SEQ ID NO;

    2,(iii) amino acid residues 190-505 shown in SEQ ID NO;

    2,(iv) amino acid residues 1-133 and 190-505 shown in SEQ ID NO;

    2,(v) the amino acid sequence shown in SEQ ID NO;

    8,(vi) amino acid residues 1-133 shown in SEQ ID NO;

    8,(vii) amino acid residues 190-506 shown in SEQ ID NO;

    8,(viii) amino acid residues 1-133 and 190-506 shown in SEQ ID NO;

    8,(ix) an amino acid sequence encoded by the nucleic acid insert of the clone contained in ATCC Deposit No. 69856,(x) the amino acid sequence encoded by the nucleic acid insert of the clone contained in ATCC Deposit No. 97222,(xi) the amino acid sequence encoded by the nucleic acid insert of the clone contained in ATCC Deposit No. 97221,(xii) the amino acid sequence encoded by the nucleic acid insert of the clone contained in ATCC Deposit No. 69874,(xiii) the amino acid sequence encoded by the nucleic acid insert of the clone contained in ATCC Deposit No. 69857,(xiv) an amino acid sequence encoded by the nucleic acid insert of the clone contained in ATCC Deposit No. 69858, or(xv) an amino acid sequence encoded by the nucleic acid insert of the clone contained in ATCC Deposit No. 69859.

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