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Array of nucleic acid probes on biological chips for diagnosis of HIV and methods of using the same

  • US 5,861,242 A
  • Filed: 01/09/1997
  • Issued: 01/19/1999
  • Est. Priority Date: 06/25/1993
  • Status: Expired due to Term
First Claim
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1. An array of oligonucleotide probes immobilized on a solid support, the array having at least four sets of oligonucleotide probes at least 9 nucleotides in length,(1) a first probe set having a probe corresponding to each nucleotide in a reference sequence from a human immunodeficiency virus, each probe being exactly complementary to a subsequence of the reference sequence that includes the corresponding nucleotide and each probe having an interrogation position occupied by a complementary nucleotide to the corresponding nucleotide,(2) three additional probe sets, each of which has a corresponding probe for each probe in the first probe set, the three corresponding probes in the three additional probe sets being identical to the corresponding probe from the first probe set or a subsequence thereof that includes the interrogation position, except that the interrogation position is occupied by a different nucleotide in each of the four corresponding probes;

  • provided the array lacks a complete set of oligonucleotide probes of a given length.

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