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Method of isolating bile duct progenitor cells

  • US 5,861,313 A
  • Filed: 06/07/1995
  • Issued: 01/19/1999
  • Est. Priority Date: 06/07/1995
  • Status: Expired due to Term
First Claim
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1. A method for isolating progenitor cells from a bile duct comprisingculturing a bile duct explant comprising both an epithelial layer and a stromal layer, which explant retains in culture the original epithelial-mesenchymal microarchitecture of a mammalian bile duct, wherein said explant is maintainable in culture for at least twenty-four hours, and wherein said explant includes at least on progenitor cell which has the ability to proliferate;

  • contacting said explant with an agent which causes proliferation of progenitor cells in said explant; and

    isolating from said explant progenitor cells that proliferate in response to said agent.

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