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Surface-enhanced raman medical probes and system for disease diagnosis and drug testing

  • US 5,864,397 A
  • Filed: 09/15/1997
  • Issued: 01/26/1999
  • Est. Priority Date: 09/15/1997
  • Status: Expired due to Fees
First Claim
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1. A probe for a surface-enhanced Raman scattering spectrometer which has a source of excitation radiation and a detector for radiation emitted from a specimen being examined, the probe comprising:

  • a member of optically transmissive material for receiving the excitation radiation from the source and for carrying the radiation emitted from the specimen to the detector, the member having an end for placing against to the specimen;

    a layer of optically transmissive material coated on the end of the member with the coating having a microstructured surface with protrusions; and

    metal material applied to the layer of optically transmissive material for producing surface enhancement of the specimen during Raman scattering spectroscopic analysis.

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