Surface-enhanced raman medical probes and system for disease diagnosis and drug testing
First Claim
1. A probe for a surface-enhanced Raman scattering spectrometer which has a source of excitation radiation and a detector for radiation emitted from a specimen being examined, the probe comprising:
- a member of optically transmissive material for receiving the excitation radiation from the source and for carrying the radiation emitted from the specimen to the detector, the member having an end for placing against to the specimen;
a layer of optically transmissive material coated on the end of the member with the coating having a microstructured surface with protrusions; and
metal material applied to the layer of optically transmissive material for producing surface enhancement of the specimen during Raman scattering spectroscopic analysis.
1 Assignment
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Accused Products
Abstract
A probe for a surface-enhanced Raman scattering spectrometer includes a member of optically transmissive material for receiving the excitation radiation from a laser and for carrying the radiation emitted from a specimen to a detector. An end of the member for placing against the specimen has a coating that produces surface enhancement of the specimen during Raman scattering spectroscopic analysis. Specifically the coating is formed by a first layer of microparticles on the member and a metal layer over the first layer. The first layer may form a microstructure surface over which a metal layer is applied. Alternatively the coating may be a material containing microparticles of a metal. An optional layer of a material may be applied to the metal layer to concentrate onto the probe compounds of analytical interest onto the probe.
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Citations
18 Claims
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1. A probe for a surface-enhanced Raman scattering spectrometer which has a source of excitation radiation and a detector for radiation emitted from a specimen being examined, the probe comprising:
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a member of optically transmissive material for receiving the excitation radiation from the source and for carrying the radiation emitted from the specimen to the detector, the member having an end for placing against to the specimen; a layer of optically transmissive material coated on the end of the member with the coating having a microstructured surface with protrusions; and metal material applied to the layer of optically transmissive material for producing surface enhancement of the specimen during Raman scattering spectroscopic analysis. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification