System for obtaining hemodynamic information

• US 5,865,758 A
• Filed: 06/11/1997
• Issued: 02/02/1999
• Est. Priority Date: 01/24/1997
• Status: Expired due to Fees

• Current Assignee: Niteq, Inc.
• Original Assignee: NITE Q Limited
• Inventors: Louzianine, Andrei G.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): LAYNO, CARL HERNANDZ
• Application Number:
  US08/873,280
• Time in Patent Office: 601 Days
• Field of Search: 600/485, 600/504, 600/508, 600/526
• US Class Current: 600/504
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives

Abstract

A system (method and apparatus) for hemodynamic measurements of the cardiac activity, including the stroke volume and cardiac output on the basis of a blood pressure pulse wave of a patient. Using a function that relates cardiac activity to an anthropometric parameter of the patient (height or arm span), ordinates of the pulse wave, and time intervals of certain characteristic points of the pulse wave, the stroke volume and/or cardiac output are obtained. The pulse wave can be determined by means of an optical sensor clipped to an ear lobe of the patient. The characteristic points and time intervals from the initial point of the pulse wave to the characteristic points are obtained under computer control. The measured values of the time intervals and ordinates are inputted to the computer which computes cardiac output, stroke volume and other cardiac information related thereto.

Claims

1. A method for determining the cardiac activity of a subject, comprising the steps of:

(a) sensing a blood-pressure pulse wave produced by the subject, which varies in magnitude with time;

(b) selecting a plurality of characteristic points on said wave;

(c) measuring time intervals from said initial point of said pulse wave to said characteristic points and measuring corresponding ordinates of said pulse wave at said characteristic points;

(d) obtaining a value corresponding to said cardiac activity from a function that relates the cardiac activity to at least one anatomical parameter of said subject, the ordinates of said blood-pressure pulse wave, and the time intervals of said biological object.

2. The method of claim 1 wherein method is repeatedly carried out and said value is obtained for each of a plurality of said pulse waves produced by said subject.

3. The method of claim 1 wherein said step of selecting a plurality of characteristic points comprises selecting point A which is the initial point at the beginning of the wave;

point B which is the point at the maximum of the first derivative of said pulse wave;

point C which is the point where the amplitude of the wave is the maximum; and

point D which is where the first derivative of the wave is at its minimum.

4. The method of claim 3, wherein said step of obtaining a value utilizes a function which is represented by the following equation:

space="preserve" listing-type="equation">CO=f.sub.1 (L)·

f.sub.2 (t.sub.E, t.sub.D, R.sub.B, R.sub.C, R.sub.D)-f.sub.3 (t.sub.D, R.sub.B, R.sub.C),

where CO is said cardiac output, L is said anatomical parameter, f₁ (L) is a function of said anatomical parameter, t_E and t_D are time intervals to said points E and D, respectively, from said point A;

R_B, R_C, R_D are values of ordinates of said blood-pressure pulse wave at said points B, C, and D, respectively.

5. The method of claim 4, wherein for a human subject said anatomical parameter L is the height H of said human subject, and where f₁ (H) has the following meaning:

f₁ (H)=H.sup.λ

/e.sup.θ

, where λ

varies within the range of 1 to 2, and where θ

varies within the range of 4 to 5.

6. The method of claim 5, wherein λ

is approximately 1.27 and 0 is approximately 4.67.

7. The method of claim 6 where f₃ (t_D, R_B, R_C)=δ

t_D /(R_B /R_C), where δ

is a constant, which varies from about 1 to 10.

8. The method of claim 5, where ##EQU4## where α

, β

, and γ

are constants and α

(sec²) is from about 0.01 to 0.1,

β

(sec^-1) is from about 0.5 to 5, and

γ

(sec) is from about 0.05 to 0.5.

9. The method of claim 8 where f₃ (t_D, R_B, R_C)=δ

t_D (R_B /R_C), where δ

is a constant in the range from about 1-10.

10. The method of claim 1 wherein f₃ is a scaling function representing the condition of the myocardium.

11. The method of claim 1 wherein said pulse wave is measured by sensing the transmission of light through an earlobe.

12. The method of claim 1 wherein said pulse wave is measured by optoelectrically sensing light transmitted through the ear lobe of the patient.

13. A method for determining the stroke volume, cardiac output or both stroke volume and cardiac output of a patient on the basis of a blood-pressure pulse waves of said patient, produced on each heart stroke comprising the steps of:

(a) providing a function presenting a mathematical model of the patient'"'"'s cardiovascular system that relates cardiac output and at least one anthropometric parameter of said patient, ordinates of said blood-pressure pulse wave, and time intervals of said blood-pressure pulse wave of said patient at a plurality of characteristic points, said characteristic points being the following;

point A of the beginning of the wave;

point B of the maximum of the first derivative of said pulse wave;

point C which is the point the amplitude of which is the maximum ordinate of said pulse wave;

point D the point where said first derivative is of the minimal value, and point E which is the end of said pulse wave and the beginning of the next pulse wave, said function being represented by the following equation;

space="preserve" listing-type="equation">CO=f.sub.1 (H)·

f.sub.2 (t.sub.E, t.sub.D, R.sub.B, R.sub.C, R.sub.D)-f.sub.3 (t.sub.D, R.sub.B, R.sub.C),

where CO is said cardiac output, H is said anthropometric parameter which is the height of said patient, f₁ (H) is a function of said height, t_E and t_D are said time intervals from said point A to said points E &

D, respectively;

R_B, R_C, R_D are values of ordinates of said blood-pressure pulse wave in said points B, C, and D, respectively;

f₃ (t_D, R_B, R_C) is a function of t_D, R_B, R_C ;

b) measuring the blood-pressure pulse wave of said patient;

c) measuring, for said characteristic points, corresponding time intervals from the initial point of said pulse wave and measuring corresponding ordinates of said pulse wave, thus obtaining measured values of said time intervals and measured values of said ordinates;

d) entering said measured values of said time intervals and said measured values of said ordinates of said characteristic points into said function;

e) calculating the stroke volume and/or cardiac output for said patient with the use of said function; and

f) repeating steps (b) to (e) for each said heart stroke.

14. The method of claim 13, wherein f₁ (H) has the following meaning:

f₁ (H)=H.sup.λ

/e.sup.θ

, where λ

varies within the range of 1 to 2, and θ

varies within the range of 4 to 5.

15. The method of claim 14, where f₂ (t_E, t_D, R_B, R_C, R_D) has the following meaning:

##EQU5## where α

, β

, and γ

are constants which are in the following ranges;

α

(sec²) from 0.01 to 0.1

β

(sec^-1) from 0.5 to 5, and

γ

(sec) from 0.05 to 0.5.

16. The method of claim 15 above where, f₃ (t_D, R_B, R_C)=δ

t_D /(R_B /R_C), where δ

is a constant from about 1-10.

17. An apparatus for measuring cardiac activity, stroke volume, or cardiac output of a biological object on the basis of a blood-pressure pulse wave of said biological object, comprising:

a pulse wave measuring unit, a data acquisition unit, a computation unit, and an indicator unit, said pulse wave measuring unit, supplying said wave to said data acquisition unit and said data acquisition unit comprising;

(a) a pulse-wave minimum/maximum measuring unit;

(b) an ordinate measuring unit;

(c) a differentiating unit;

(d) a controller;

(e) a time interval measuring unit; and

(f) a pulse-wave derivative minimum/maximum measuring unit, said controller being responsive to units (a) and (f) and controlling when said units (b), (d) and (e) provide inputs to said computation unit.

18. The apparatus of claim 17, wherein said pulse wave measuring unit comprises an optical ear lobe sensor.

19. The apparatus of claim 17 wherein said data acquisition unit comprises a computer programmed in accordance with a flow chart of (FIG. 2A) to provide the functions of units (a) through (e).

20. The apparatus of claim 19 wherein said computation unit is provided by a computer programmed in accordance with said flow chart to compute said cardiac activity.