Stabilized naloxone formulations
First Claim
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1. A parenteral pharmaceutical composition autoclaved for sterilization, wherein the pH is about 3.0-3.5, comprising:
- a) an effective amount of 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one;
b) a suitable acidic or buffer component;
c) a stabilizing agent; and
d) a tonicity adjusting agent.
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Abstract
Physically and chemically stable pharmaceutical compositions useful for administering naloxone by injection are described. These compositions are essentially aqueous solutions having a pH between 3.0-3.5, and containing naloxone, an acidic or buffer component, a tonicity-adjusting agent, and a stabilizing agent, said composition being optionally sterilized by autoclaving.
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9 Claims
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1. A parenteral pharmaceutical composition autoclaved for sterilization, wherein the pH is about 3.0-3.5, comprising:
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a) an effective amount of 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one; b) a suitable acidic or buffer component; c) a stabilizing agent; and d) a tonicity adjusting agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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Specification