Local delivery of estrogen for angiogenesis
First Claim
1. A method for increasing blood flow to ischemic tissue proximal to a constricted blood vessel region comprising the step of inducing angiogenesis in a less constricted blood vessel region proximal to said constricted region by applying an effective amount of estrogen compound for causing angiogenesis to said less constricted blood vessel region.
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Abstract
A method for inducing angiogenesis in blood vessels proximal to ischemic tissue or proximal to stenosed regions including application of an estrogen compound to the blood vessel walls at a treatment site proximal to or upstream of the stenosis. A preferred delivery device is a double walled drug delivery catheter having porous outer walls. Another suitable delivery device is a drug injection device for injecting angiogenic material into blood vessel walls. One delivery method utilizes iontophoresis.
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Citations
9 Claims
- 1. A method for increasing blood flow to ischemic tissue proximal to a constricted blood vessel region comprising the step of inducing angiogenesis in a less constricted blood vessel region proximal to said constricted region by applying an effective amount of estrogen compound for causing angiogenesis to said less constricted blood vessel region.
Specification