Local delivery of estrogen for angiogenesis

• US 5,866,561 A
• Filed: 08/21/1997
• Issued: 02/02/1999
• Est. Priority Date: 08/21/1997
• Status: Expired due to Term

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Inventors: Ungs, Mark T.
• Primary Examiner(s): Schenkman, Leonard
• Application Number:
  US08/916,430
• Time in Patent Office: 530 Days
• Field of Search: 514/182
• US Class Current: 514/182
• CPC Class Codes: A61K 31/565 not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
• CPC Class Codes: A61L 2300/222 Steroids, e.g. corticosteroids
• CPC Class Codes: A61L 2300/412 Tissue-regenerating or healing or proliferative agents
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence

Abstract

A method for inducing angiogenesis in blood vessels proximal to ischemic tissue or proximal to stenosed regions including application of an estrogen compound to the blood vessel walls at a treatment site proximal to or upstream of the stenosis. A preferred delivery device is a double walled drug delivery catheter having porous outer walls. Another suitable delivery device is a drug injection device for injecting angiogenic material into blood vessel walls. One delivery method utilizes iontophoresis.

Claims

1. A method for increasing blood flow to ischemic tissue proximal to a constricted blood vessel region comprising the step of inducing angiogenesis in a less constricted blood vessel region proximal to said constricted region by applying an effective amount of estrogen compound for causing angiogenesis to said less constricted blood vessel region.

2. The method of claim 1, wherein said method further comprises providing an application device, wherein said application device is a balloon catheter.

3. The method of claim 1, wherein said less constricted blood vessel region has walls and said applying step includes depositing said compound on said walls.

4. The method of claim 1, wherein said applying device is a double walled balloon catheter having a porous outer wall.

5. The method of claim 4, wherein said catheter includes a perfusion lumen.

6. The method of claim 1, wherein said less constricted blood vessel region has walls, said application device is an injection device, and said applying step includes injecting said compound into said walls.

7. The method of claim 1, wherein said estrogen compound is selected from the group consisting of estradiol(E2) and estriol(E3).

8. The method of claim 1, wherein said estrogen compound is 17-Beta Estrodiol.

9. The method of claim 1, wherein said less constricted blood vessel region has walls, and said method includes providing an application device including an iontophoresis device and said applying step includes depositing said compound on said walls and transporting said compound through said walls utilizing said iontophoresis device.