Apparatus for forming liquid droplets having a mechanically fixed inner microtube

• US 5,868,322 A
• Filed: 09/27/1996
• Issued: 02/09/1999
• Est. Priority Date: 01/31/1996
• Status: Expired due to Term

• Current Assignee: Agilent Technologies, Inc.
• Original Assignee: Hewlett-Packard Company (HP Inc.)
• Inventors: Fischer, Steven M., Gourley, Darrell L., Loucks, Harvey D. Jr.
• Primary Examiner(s): Kashnikow, Andres
• Assistant Examiner(s): Douglas, Lisa Ann
• Application Number:
  US08/722,644
• Time in Patent Office: 865 Days
• Field of Search: 239/418, 239/423, 239/424, 239/433, 239/434, 73/864.81
• US Class Current: 239/418
• CPC Class Codes: B05B 13/0278 Arrangement or mounting of spray heads B05B13/0207 takes precedence
• CPC Class Codes: B05B 15/60 Arrangements for mounting, supporting or holding spraying apparatus
• CPC Class Codes: B05B 5/0255 spraying and depositing by electrostatic forces only
• CPC Class Codes: B05B 7/066 with an inner liquid outlet surrounded by at least one annular gas outlet
• CPC Class Codes: B05B 7/068 the annular gas outlet being supplied by a gas conduit having an axially concave curved internal surface just upstream said outlet
• CPC Class Codes: B05B 7/0876 to form parallel jets constituted by a liquid or a mixture containing a liquid B05B7/0884, B05B7/0892 take precedence
• CPC Class Codes: G01N 2030/847 by pneumatic means
• CPC Class Codes: G01N 30/7246 by pneumatic means
• CPC Class Codes: H01J 49/0431 for liquid samples interfaces to liquid chromatographs G01N30/7233
• CPC Class Codes: H01J 49/167 Capillaries and nozzles specially adapted therefor; electrostatic spraying per se B05B5/00

Abstract

The invention relates to an apparatus for forming liquid droplets, such as a micro nebulizer, useful for preparing samples for subsequent analysis via MS, AA, ICP, CE/MS, and similar analytical systems. The apparatus has a mechanically stabilized inner microtube or needle, thereby ensuring controllably uniform droplet size The mechanical stabilization is provided by securing the inner microtube or needle, such as by narrowing the inner diameter of the outer microtube or otherwise narrowing the annular intermediate space between the inner and outer microtubes for a predetermined length. Thus, the inner microtube is secured in a centered or otherwise predetermined fixed radial position, with minimum perturbation of the fluid flow. Further, a tip, when coupled with the exit end of the outer microtube, provides a region in which the sheath fluid flow in the outer microtube stabilizes prior to both exiting the tip and colliding with the liquid analyte exiting the inner microtube.

Claims

1. An apparatus for forming droplets from a liquid comprising:

A. at least one inner microtube having an outer wall, an exit end, and an exit end aperture,

B. an outer microtube having an inner wall, an exit end, and an exit end aperture, wherein the inner microtube has an outer diameter smaller than the inner diameter of the outer microtube, and the inner microtube is positioned within and is surrounded by the outer microtube such that an annular intermediate space is formed therebetween, with the exit end of each microtube being located at a same end of the apparatus,

C. one or more intermediate structures either (i) extending inward radially from the inner wall of the outer microtube and contacting the outer wall of the inner microtube for a predetermined length, (ii) extending outward radially from the outer wall of the inner microtube and contacting the inner wall of the outer microtube for a predetermined length, or (iii) spanning the annular intermediate space and contacting both the outer wall of the inner microtube and the inner wall of the outer microtube for a predetermined length, wherein the intermediate structure is situated so as to mechanically stabilize the inner microtube, and

D. one or more communicating channels continuing lengthwise along the outside of the inner microtube, wherein the communicating channel provides a continuation of the annular intermediate space and through which a fluid may continue to flow after encountering the intermediate structure.

2. The apparatus of claim 1, further comprising:

E. a tip which couples with a surface at the exit end of the outer microtube, thereby forming a region near the exit ends of the microtubes within which fluid flow stabilizes.

3. The apparatus of claim 2, wherein the inner microtube, the outer microtube, and the tip each has an outer surface which is chamfered, angled, or tapered.

4. The apparatus of claim 1, wherein the outer microtube and the inner microtube are concentrically positioned along a common center axis.

5. The apparatus of claim 1, wherein the outer microtube and the inner microtube are eccentrically positioned along substantially parallel axes.

6. The apparatus of claim 1, wherein the length for which the inner diameter of the outer microtube is narrowed is for a length of about four to about ten times the outer diameter of the inner microtube.

7. The apparatus of claim 6, wherein the inner microtube has an outer surface which is chamfered, angled, or otherwise tapered at the exit end such that the outer surface of the exit end terminates in a less than or about a ninety degree angle.

8. The apparatus of claim 6, comprising three communicating channels, wherein the each of the channels is radially equidistant from each of the others and is substantially parallel to the inner microtube.

9. The apparatus of claim 1, wherein the exit end of the inner microtube is recessed with respect to the exit end of the outer microtube.

10. A mass spectrometer system comprising the apparatus of claim 1.