Quantitative characterization of fibrillatory spatiotemporal organization
First Claim
1. A method for characterizing the spatiotemporal organization of atrial fibrillation, comprising the steps of:
- (a) acquiring electrogram signals during atrial fibrillation from a plurality of sites adjacent to a region of atrial tissue;
(b) determining activation patterns from said electrogram signals; and
(c) determining spatiotemporal organization of electrical propagation from said activation patterns.
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Abstract
Described is a method for monitoring the spatiotemporal organization of atrial arrhythmias, especially atrial fibrillation, based on an analysis of sequences of activation patterns obtained from a particular set of atrial recording sites. This analysis measures the degree of order change in the sequence of activation patterns, or of the time between order changes. Electrogram signals produced by atrial fibrillation are acquired simultaneously from sites adjacent to atrial tissue using multipole electrode catheters. These signals subsequently are filtered and processed to obtain a group of time series which manifest peaks at the latencies of maximal energy in the original data; when these peaks occur are the latencies that are defined as activation events. The activation events from each sampled site are ordered with respect to activation events from each of the other sites, and are translated into corresponding activation patterns, which are determined by the specific spatiotemporal activation sequence associated with each activation event. Each activation pattern in the sequence then is compared with subsequent observed patterns to determine if any spatiotemporal order change has occurred, and if so, to what extent; also, the distribution of observed activation patterns is evaluated for an additional characterization of atrial fibrillation.
145 Citations
54 Claims
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1. A method for characterizing the spatiotemporal organization of atrial fibrillation, comprising the steps of:
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(a) acquiring electrogram signals during atrial fibrillation from a plurality of sites adjacent to a region of atrial tissue; (b) determining activation patterns from said electrogram signals; and (c) determining spatiotemporal organization of electrical propagation from said activation patterns. - View Dependent Claims (2, 3)
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4. A method for detecting and characterizing the spatiotemporal organization of atrial fibrillation based upon the spatiotemporal relationship of activation events detected at sites representing spatial samples within an atrial region of interest, comprising the steps of:
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(a) simultaneously acquiring electrogram signals during atrial fibrillation from a plurality of sites adjacent to a region of atrial tissue; (b) determining the latencies of the activation events at each site; (c) determining sequences of activation patterns from said activation event latencies; and (d) translating said sequences of activation patterns to sequences of spatiotemporal patterns having a common spatiotemporal reference. - View Dependent Claims (5, 6)
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7. A method for detecting and characterizing the spatiotemporal organization of atrial fibrillation based upon the spatiotemporal relationship of activation events detected at sites representing spatial samples within an atrial region of interest, comprising the steps of:
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(a) simultaneously acquiring electrogram signals during atrial fibrillation from a plurality of sites adjacent to a region of atrial tissue; (b) determining activation events at each site from said electrogram signals; (c) determining sequences of activation patterns from said activation events; and (d) determining spatiotemporal organization of electrical propagation within said atrial region of interest from said sequences of activation patterns wherein atrial fibrillation is detected and characterized from said spatiotemporal organization. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51)
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52. A method for mapping atrial fibrillation by assessing spatiotemporal organization at multiple targeted atrial regions, comprising the steps of:
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(a) simultaneously acquiring electrogram signals during atrial fibrillation from a plurality of sites adjacent to each targeted region of atrial tissue; (b) determining activation events at each site from said electrogram signals; (c) determining sequences of activation patterns for each targeted region from the activation events associated with that region; (d) determining spatiotemporal organization of electrical propagation within each targeted atrial region from sequences of activation patterns associated with that region; and (e) comparing spatiotemporal organization in different atrial regions wherein atrial fibrillation can be detected and characterized from said comparison. - View Dependent Claims (53, 54)
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Specification