Indwelling catheter with stable enzyme coating
First Claim
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1. A catheter for use in a body having bodily fluids of a patient, the catheter comprising:
- an elongated tubular element formed from a polymeric material and adapted for placement in the body of the patient, the tubular element defining a catheter lumen and a surface; and
a long-term stabilized surface coating applied to the tubular element on at least a portion of the surface, the surface coating including at least one enzyme to dissolve occlusions along the catheter lumen and at least one coating material, and wherein the at least one coating material protects the enzyme and regulates degradation upon contact with the bodily fluids of the patient.
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Abstract
An improved indwelling catheter adapted for long-term usage includes a stable enzyme coating to prevent occlusion of the catheter lumen. The enzyme coating includes a fibrinolytic and/or lipolytic enzyme incorporated in a catheter coating to resist or control proteolytic degradation, thereby maintaining the enzyme in an active state for dissolving clots and occlusions within the catheter lumen over an extended period of time.
76 Citations
19 Claims
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1. A catheter for use in a body having bodily fluids of a patient, the catheter comprising:
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an elongated tubular element formed from a polymeric material and adapted for placement in the body of the patient, the tubular element defining a catheter lumen and a surface; and a long-term stabilized surface coating applied to the tubular element on at least a portion of the surface, the surface coating including at least one enzyme to dissolve occlusions along the catheter lumen and at least one coating material, and wherein the at least one coating material protects the enzyme and regulates degradation upon contact with the bodily fluids of the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification