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Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems

  • US 5,869,004 A
  • Filed: 06/09/1997
  • Issued: 02/09/1999
  • Est. Priority Date: 06/09/1997
  • Status: Expired due to Term
First Claim
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1. A microfluidic system for diluting a material in a microfluidic device, the system comprising:

  • a microfluidic device having at least a first main channel disposed therein, said main channel having at least one microscale cross-sectional dimension;

    at least a first source of said material in fluid communication with said main channel at a first point alone a length of said main channel;

    at least a first diluent source in fluid communication with said main channel at a second point along said length of said main channel;

    at least a first reservoir in fluid communication with said main channel at a third point along said length of said main channel;

    at least a second diluent source in fluid communication with said main channel at a fourth point along said length of said main channel; and

    a fluid direction system for delivering diluent and material to said main channel from said first diluent source and said material source, respectively, combining said first diluent with said material to form first diluted material, transporting a first portion of said first diluted material out of said main channel into said first reservoir, a second portion of said first diluted material remaining in said main channel, and for second delivering diluent from said second diluent source into said main channel to mix with said second portion of first diluted material.

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