Chemically driven liquid delivery pumping device

• US 5,871,125 A
• Filed: 09/05/1996
• Issued: 02/16/1999
• Est. Priority Date: 09/05/1995
• Status: Expired due to Fees

• Current Assignee: Elan Pharma International Limited (Perrigo Company PLC)
• Original Assignee: Elan Medical Technologies Ltd. (Perrigo Company PLC)
• Inventors: Gross, Joseph
• Primary Examiner(s): Kashnikow, Andres
• Assistant Examiner(s): DEAL, DAVID R
• Application Number:
  US08/697,692
• Time in Patent Office: 894 Days
• Field of Search: 222/207, 222/214, 222/389, 222/399, 604/82, 604/83, 604/131, 604/141, 604/142, 604/145, 604/147, 604/896, 604/407, 604/416
• US Class Current: 222/207
• CPC Class Codes: A61M 5/1413 Modular systems comprising interconnecting elements
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/155 pressurised by gas introduced into the reservoir
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence

Abstract

A liquid delivery pumping device for the delivery of liquids enterally or parenterally comprises a housing including a gas generating chamber, wherein a gas is generated intermittently when two reactants, such as the components of an effervescent couple, are caused to react, a pumping chamber for a reciprocating pumping unit operable by the gas and to which chamber the gas is conveyed once generated, the pumping unit forming part of a mechanism which receives and regulates the liquid to be delivered in response to the reciprocation of the pumping unit, and means for controlling the gas pressure within the pumping chamber to enable controlled reciprocation of the pumping unit. The device provides precisely controlled rates of liquid delivery to a patient irrespective of the viscosity of the liquid to be delivered.

Claims

1. A liquid delivery device comprising a housing, a pumping chamber within the housing, gas generating means comprising reactants which when brought into contact generate a gas which pressurizes said pumping chamber, a pumping mechanism having a pumping member within the pumping chamber, said member being reciprocable in response to changes in pumping chamber pressure, wherein the reciprocation of the pumping member causes a liquid to be drawn from a liquid supply and pumped towards an outlet, and means for controlling the pressure within the pumping chamber to enable controlled reciprocation of the pumping member.

2. A device according to claim 1, wherein the means for controlling the pressure within the pumping chamber comprises a vent having associated control means.

3. A device according to claim 2, wherein the vent is an electronically controlled valve unit which when actuated releases gas from said pumping chamber.

4. A device according to claim 2, wherein the vent comprises an electromagnetically actuated valve member for selectively causing a venting aperture in the housing to be blocked and unblocked.

5. A device according to claim 1, wherein the pumping mechanism comprises valve means for causing liquid to be drawn from the liquid supply into the pumping mechanism and subsequently pumped from the pumping mechanism towards the outlet upon the reciprocation of the pumping member through a cycle.

6. A device according to claim 1, wherein the pumping member is in the form of a convoluted diaphragm.

7. A device according to claim 6, wherein the diaphragm is in the form of a bellows.

8. A device according to claim 7, wherein the bellows has inner and outer walls defining a channel therebetween through which gas can escape to atmosphere if the outer wall of the bellows is perforated.

9. A device according to claim 7, wherein the bellows comprises an elastic member which when relaxed causes the bellows to be extended but which can be elastically deformed allowing the bellows to be compressed under an increased chamber pressure.

10. A device according to claim 7, wherein liquid is drawn into the bellows and pumped therefrom during a cycle of reciprocation of the bellows, such that the volume of liquid which is pumped during each cycle of reciprocation is equal to the difference between the extended and compressed bellows volumes.

11. A device according to claim 7, wherein the means for controlling the pressure causes the pumping chamber pressure to vary cyclically, the cycle comprising a compression phase during which the pumping chamber is pressurized by the generation of gas to a sufficient pressure and for a sufficient time to cause the bellows to be compressed to a predetermined extent, and a relaxation phase during which the pumping chamber is depressurized by a sufficient amount and for a sufficient length of time to allow the bellows to re-extend to a draw in mined degree and thereby draw in a fixed volume of liquid to be pumped during the following cycle.

12. A device according to claim 7, wherein the pumping member is a first bellows and the pumping mechanism includes a second bellows cooperating with the first bellows such that the first bellows is operated on by said gas to cause reciprocation of the second bellows.

13. A device according to claim 12, wherein the pumping mechanism and the second bellows form a unit which is detachable from the device for reuse once the gas generating reactants are exhausted.

14. A device according to claim 12, wherein any gas escaping through the first bellows vents to the atmosphere.

15. A device according to claim 1, wherein the gas generating means comprises first and second compartments, each containing a reactant, said compartments being interconnected in a manner which permits the flow, in use, of a reactant from the first compartment to contact the other reactant.

16. A device according to claim 1, wherein the reactants are two reactants which consist of the components of an effervescent couple.

17. A device according to claim 16, wherein the reactants are citric acid and either sodium bicarbonate or sodium carbonate and the gas generated is carbon dioxide.

18. A device according to claim 1, wherein at least one rupturable seal separates said reactants prior to the reaction of and generation of gas thereby.

19. A device according to claim 1, further comprising a gas generation chamber in which said gas is generated and which is in communication with said pumping chamber.

20. A device according to claim 19, further comprising blocking means for preventing further ingress of gas into the pumping chamber while gas is being released therefrom.

21. A device according to claim 20 wherein said blocking means is incorporated into said pressure controlling means.

22. A device according to claim 21, wherein said blocking means comprises a blocking member which is controllably movable from a first position, in which it blocks a venting aperture between the pumping chamber and the atmosphere, to a second position in which it blocks communication between the gas generation chamber and the pumping chamber, such that the movement of the blocking member between the first and second positions enables the pumping chamber to be selectively pressurized and depressurized.

23. A device according to claim 19, wherein an increase in pressure within the gas generation chamber prevents continued mixing of the reactants.

24. A device according to claim 23, wherein one of said reactants is in liquid form and flows from a compartment into contact with at least one of the other of said reactants and wherein an increase in pressure within the gas generation chamber reduces the rate of flow of said one of said reactants.

25. A device according to claim 24, wherein the pumping member is in the form of a convoluted diaphragm.

26. A device according to claim 1, wherein the gas generating means enables a gas to be generated intermittently.