Methods for treatment or prevention of neurodegenerative conditions using immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
First Claim
1. A method for treatment a neurodegenerative condition in a patient comprising implanting in the patient at least one immunoisolatory vehicle comprising:
- (a) a core comprising a volume of at least 1 μ
l and at least 104 living cells which secrete at least one biologically active product, said cells being dispersed in a biocompatible matrix comprising a hydrogel or extracellular matrix components, and(b) an external jacket surrounding the core, the jacket comprising a biocompatible hydrogel that does not ionically bond to a core, matrix material during formation of the jacket, the jacket being free of cells projecting externally thereof, said jacket having a molecular weight cutoff permitting passage of the biologically active product from the core through the jacket.
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Accused Products
Abstract
A method for treatment of a neurodegenerative condition in a patient comprising implanting in the patient at least one immunoisolatory vehicle comprising a corc comprising a volume of at least 1 μl and at least 104 living cells which secrete at least one biologically active product, said cells being dispersed in a biocompatible matrix comprising a hydrogel or extracellular matrix components, and an external jacket surrounding the core, the jacket comprising a biocompatible hydrogel or thermoplastic, the jacket being free of cells projecting externally thereof, said jacket having a molecular weight cutoff permitting the passage of the biologically active product from the core through the jacket.
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Citations
45 Claims
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1. A method for treatment a neurodegenerative condition in a patient comprising implanting in the patient at least one immunoisolatory vehicle comprising:
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(a) a core comprising a volume of at least 1 μ
l and at least 104 living cells which secrete at least one biologically active product, said cells being dispersed in a biocompatible matrix comprising a hydrogel or extracellular matrix components, and(b) an external jacket surrounding the core, the jacket comprising a biocompatible hydrogel that does not ionically bond to a core, matrix material during formation of the jacket, the jacket being free of cells projecting externally thereof, said jacket having a molecular weight cutoff permitting passage of the biologically active product from the core through the jacket. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 26, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45)
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13. A method for treatment of a neurodegenerative condition in a patient comprising implanting in the patient at least one immunoisolatory vehicle comprising:
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(a) a core comprising a volume of at least 1 μ
l and at least 104 living cells which secrete at least one biologically active product, said cells being dispersed in a biocompatible matrix comprising a hydrogel or extracellular matrix components, and(b) an external jacket surrounding the core, the jacket comprising a biocompatible thermoplastic, the jacket being free of said cells projecting externally thereof, said jacket having a molecular weight cutoff permitting passage of the biologically active product from the core through the jacket into the patient'"'"'s body. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 27)
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Specification