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DNA sequencing by mass spectrometry via exonuclease degradation

  • US 5,872,003 A
  • Filed: 05/30/1995
  • Issued: 02/16/1999
  • Est. Priority Date: 03/19/1993
  • Status: Expired due to Term
First Claim
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1. A system for exonuclease-mediated mass spectrometric sequencing comprising:

  • (i) a reactor and capillary tube means for performing and containing exonuclease cleavage reactions of the target nucleic acids, the cleavage reaction forming a train of sequentially released individual nucleotides;

    (ii) mass spectrometric means for detecting the train of individual nucleotides released by the exonuclease cleavage of the target nucleic acid; and

    (iii) transfer means for transferring the train of individual nucleotides from the reactor means to the mass spectrometric means.

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