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Phenyl-oxo-alkyl-(4-piperidinyl)benzoate derivatives

  • US 5,872,131 A
  • Filed: 03/24/1997
  • Issued: 02/16/1999
  • Est. Priority Date: 09/27/1994
  • Status: Expired due to Term
First Claim
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1. A compound of formula (I) ##STR14## a N-oxide form, a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, wherein:

  • R1 is halo or C1-6 alkylsulfonylamino;

    either R2 is hydrogen and R3 is C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl;

    orR2 and R3 taken together form a bivalent radical of formula;

    
    
    space="preserve" listing-type="equation">--CH═

    CH-- (a),
    
    
    space="preserve" listing-type="equation">--(CH.sub.2).sub.2 -- (b),or
    
    
    space="preserve" listing-type="equation">--(CH.sub.2).sub.3 -- (c);

    in the bivalent radicals of formula (a), (b) or (c) one or two hydrogen atoms may be replaced by C1-6 alkyl;

    Alk is C1-6 alkanediyl;

    R4 is hydrogen or C1-6 alkyloxy;

    R5, R6 and R7 each independently are hydrogen, halo, C1-6 alkyl, C1-6 alkyloxy;

    or R5 and R6 taken together may also form a bivalent radical of formula;

    ##STR15## R8 and R9 each independently are hydrogen or C1-6 alkyl;

    R10 is hydrogen, C1-6 alkylcarbonyl, C1-6 alkyloxycarbonyl;

    m is 1 or 2.

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