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Vitamin D analogues

  • US 5,872,140 A
  • Filed: 03/21/1996
  • Issued: 02/16/1999
  • Est. Priority Date: 07/23/1993
  • Status: Expired due to Fees
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First Claim
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1. A compound having a formula (II) ##STR11## where R1 represents a methyl group having α

  • - or β

    - configuration;

    W represents a valence bond or a C1-5 alkylene group; and

    A=represents ##STR12## where R6 and R7, which may be the same or different, each represent a hydrogen atom or an O-protecting group which is an etherifying group which is a tri(C1-6 alkyl)silyl, tri(C6-12 aryl)silyl or mixed C1-6 alkyl-C6-12 arylsilyl group, a C1-6 alkyl group optionally interrupted by an oxygen atom or a tetrahydropyranyl group or is an esterifying group which is a C1-6 alkanoyl group, an aroyl group containing 7-15 carbon atoms, a C1-6 alkane sulphonyl group optionally substituted with a halogen atom or a p-toluene sulphonyl group;

    Y represents a valence bond or a C1-3 alkylene group attached to the 4- or 5-position of the triazole ring; and

    Z represents a group --C(R4)(R5).OH in which R4 and R5 may be the same or different and are selected from the group consisting of hydrogen atoms, C1-6 alkyl, C3-8 cycloalkyl, C6-12 aryl C1-4 alkyl and optionally substituted C6-12 aryl groups wherein the substituent is a halogen atom, a C1-4 alkyl group, a C1-4 alkoxy group, a C1-4 alkanoyl group, a C1-4 alkyl amino group, a di (C1-4 alkyl) amino, a nitro group, a carbamoyl group or a C1-4 alkanoyl amino group;

    or R4 and R5 together with the carbon atom to which they are attached form a C3-8 carbocyclic ring.

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