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Hydroxy-amino acid amides

  • US 5,872,262 A
  • Filed: 12/08/1997
  • Issued: 02/16/1999
  • Est. Priority Date: 11/05/1996
  • Status: Expired due to Fees
First Claim
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1. A compound of Formula Iwherein:

  • R1 and R3 are independently chosen from the group consisting of alkyl, alkoxyalkyl, 2-pyridinylmethyl, 3-pyridinylmethyl and arylalkyl;

    R2 is H or S--C(O)--L--;

    wherein;

    S is a solid support; and

    --L-- is a linker of Formula(a) ##STR31## wherein the left-hand bond is the point of attachment to --C(O)-- and the right-hand bond is the point of attachment to the amide nitrogen of Formula I;

    Y is --C(O)R5wherein;

    R5 is ##STR32## wherein R6 and R7 are independently chosen from the group consisting of substituted alkyl, alkylcarbonyl and substituted alkylcarbonyl; and

    R8 is alkyl.

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