Massively parallel detection
First Claim
1. An apparatus for measuring the amount of light emitted from or transmitted through two or more detection sites of a first set of detection sites on a planar substrate while spatially resolving the measurements for each detection site of the first set, the apparatus comprising:
- for each detection site of the first set, an addressable source of a light beam directed to that detection site at a first angle; and
an array detector comprising a plurality of light responsive pixels, wherein for each detection site of the first set there is at least one light responsive pixel that receives light emitted from or transmitted through that detection site at a second angle.
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Accused Products
Abstract
The invention provides apparatuses for detecting light from, for example, closely spaced detection sites. In one embodiment, the invention provides an apparatus for measuring the amount of light emitted from or transmitted through two or more detection sites of a first set of detection sites on a planar substrate while spatially resolving the measurements for each detection site of the first set, the apparatus comprising: for each detection site of the first set, an addressable source of a light beam directed to that detection site at a first angle; and an array detector comprising a plurality of light responsive pixels, wherein for each detection site of the first set there is at least one light responsive pixel that receives light emitted from or transmitted through that detection site at a second angle that can be the same as the first angle.
251 Citations
25 Claims
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1. An apparatus for measuring the amount of light emitted from or transmitted through two or more detection sites of a first set of detection sites on a planar substrate while spatially resolving the measurements for each detection site of the first set, the apparatus comprising:
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for each detection site of the first set, an addressable source of a light beam directed to that detection site at a first angle; and an array detector comprising a plurality of light responsive pixels, wherein for each detection site of the first set there is at least one light responsive pixel that receives light emitted from or transmitted through that detection site at a second angle. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. An apparatus for measuring the amount of light emitted from a first set of two or more detection sites on a planar substrate while spatially resolving the measurements from each first set detection site and for measuring the amount of light emitted from a second set of two or more detection sites on a planar substrate while spatially resolving the measurements from each second set detection site, the apparatus comprising:
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a source of a light beam directed towards the planar substrate at a first angle; a means to separately illuminate the first and second set detection sites; one or more lenses for focusing light emitted from each of the first or second set detection sites and having a second angle having an angle offset from the first angle, onto a unique area of an array detector; and the array detector comprising a plurality of light responsive pixels, wherein for each first set detection site there is at least one light responsive pixel that receives light emitted from that detection site and substantially no cross-talk from another first set detection site, wherein for each second set detection site there is at least one light responsive pixel that receives light emitted from that detection site and substantially no cross-talk from another second set detection site, wherein the first set detection sites are distinct from the second set detection sites. - View Dependent Claims (23, 24, 25)
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Specification