Tomosynthesis system for breast imaging

• US 5,872,828 A
• Filed: 07/22/1997
• Issued: 02/16/1999
• Est. Priority Date: 07/23/1996
• Status: Expired due to Term

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Niklason, Laura E., Kopans, Daniel B., Niklason, Loren T.
• Primary Examiner(s): Porta, David P.
• Assistant Examiner(s): Bruce, David Vernon
• Application Number:
  US08/898,058
• Time in Patent Office: 574 Days
• Field of Search: 378/22, 378/23, 378/37
• US Class Current: 378/23
• CPC Class Codes: A61B 6/025 Tomosynthesis
• CPC Class Codes: A61B 6/4233 using matrix detectors
• CPC Class Codes: A61B 6/502 for diagnosis of breast, i.e. mammography
• CPC Class Codes: G06T 11/006 Inverse problem, transformation from projection-space into object-space, e.g. transform methods, back-projection, algebraic methods
• CPC Class Codes: G06T 2211/436 Limited angle

Abstract

The invention includes both systems and methods for tomosynthesis x-ray imaging. An x-ray source is moved at various positions in an arc around an object, e.g., a breast, to illuminate a stationary digital detector (or its equivalent) placed at an image plane behind the object. A digital image data processor collects data from the detector and a motion controller moves the source around the object. As the source moves along the arc, the detector generates, for a succession of points along the arc, a corresponding succession of image data sets, each set being representative of the intensity of x-rays incident on the detector for the then current position of the source. The image data processor is responsive to the image data sets to generate an output image signal representative of the x-ray absorption of points within the object region. The processor transforms the image plane data to a form corresponding to that which would have been generated had the x-ray source moved in a linear motion in a source plane parallel to the image plane, rather than an arc. The resultant image data thus corresponds in form to that produced by a conventional linear motion, e.g., Twinning-type, system, so that conventional techniques and equipment may be used to produce a final representation of the x-ray absorption of the object region.

Claims

1. System for performing digital tomosynthesis on an object region, comprising:

a stationary x-ray detector for detecting x-ray radiation transmitted through the object region and for producing image data representative of the intensity of the radiation;

a moveable x-ray source for generating the x-ray radiation;

a motion controller for moving the x-ray source to a plurality of positions defining an arc about the region; and

a data processor for determining x-ray absorption points within the region based upon an image data set having image data corresponding to each of the positions.

2. System according to claim 1, wherein the data processor comprises means for generating an image signal representing the region as a spatial map of the points, each point defining absorptivity of x-ray radiation within the region.

3. System according to claim 1, wherein the arc spans a plane and has an axis of rotation on a line in the plane that is perpendicular to the detector and that extends through approximately the center of the detector.

4. System according to claim 3, wherein the object region is disposed about an object plane, the data processor further comprising means for transforming the image data to a form representative of the expected intensity of x-ray radiation generated by the source at an offset position defined by the intersection between (a) a line in the plane of the arc that is substantially parallel to the object plane, and (b) a line in the plane of the arc defined by the axis of rotation and by one of the positions corresponding to the image data.

5. System according to claim 3, wherein the intersection between the axis of rotation and the plane of the arc defines a center of rotation that is between the source and the detector.

6. System according to claim 1, wherein the line that is substantially parallel to the object plane is also tangential to the arc.

7. System according to claim 1, wherein the source comprises an x-ray tube.

8. System according to claim 1, wherein the detector comprises an array of x-ray detector elements and wherein the image data comprises a plurality of intensity data values, each of the values corresponding to x-ray radiation detected by each of the elements.

9. System according to claim 1, wherein the detector comprises a two-dimensional array of detector elements and wherein the image data comprises a plurality of intensity data values, each of the values corresponding to each of the elements.

10. System according to claim 1, wherein the controller comprises a first rigid support structure having a proximal end located at about a center of rotation of the arc and a distal end for rigidly supporting the detector.

11. System according to claim 10, wherein the controller comprises a second rigid support structure having a first end pivotably connected to the proximal end of the first support structure at the center of rotation and having a second end for supporting the source at a fixed distance from the center of rotation, wherein the source is rotatable about the center of rotation and along the arc.

12. System according to claim 11, wherein the source is constructed and arranged to irradiate x-ray radiation substantially aligned with the second support structure and towards the center of rotation.

13. System according to claim 11, further comprising an actuator, responsive to angular control signals from the controller, for moving the source to an angle formed between the first and second support structures, the angle being indicative of one of the positions.

14. System according to claim 11, wherein the controller comprises means for determining an angle between the first and second support structures.

15. System according to claim 1, wherein the controller comprises means for determining an angle formed between (a) a line perpendicular to the detector and extending through a center of rotation of the arc and (b) a line defined by the center of rotation and a location of the source on the arc.

16. System according to claim 1, wherein the controller comprises a computer having means for selectively controlling the position of the source along the arc.

17. System according to claim 1, wherein the data processor comprises a computer.

18. System according to claim 17, wherein the computer further includes means for controlling the motion controller to move the source selectively along the arc.

19. System according to claim 17, wherein the source is responsive to the computer to turn the source on and off selectively.

20. System according to claim 1, wherein the detector comprises a plurality of scintillator elements and associated photodetectors, each photodetector producing a digitized signal representing x-ray flux intensity for one of the elements.

21. System according to claim 1, wherein the detector comprises an integrated circuit array.

22. System according to claim 1, further comprising an x-ray gantry having (a) a first arm for pivotably supporting the source about the center of rotation and (b) a second arm for rigidly supporting the detector relative to the center of rotation.

23. System according to claim 22, further comprising a computer for controlling the gantry so as to move the source to selected positions corresponding to an angle formed between the first and second arms.

24. System according to claim 1, wherein the detector comprises a cesium iodide phosphor on an amorphous silicon photodiode array.

25. A method for tomosynthesis x-ray imaging of an object, comprising the steps of:

(A) irradiating the object, with x-ray radiation, from a series of positions defining an arc about the region, the arc spanning a plane intersecting the object and having an axis of rotation on a line in the plane and perpendicular to the array,

(B) detecting the radiation transmitted through the object with a stationary detector array and storing image data for each of the positions, the image data being representative of x-ray intensity values, and

(C) determining x-ray absorption points within the object based upon an image data set having image data corresponding to each of the positions.

26. A method according to claim 25, further comprising the step of transforming the image data, for each of the positions, to a form representative of the expected intensity of the radiation generated at an offset position defined by the intersection between (a) a line in the plane that is substantially parallel to the array, and (b) a line in the plane defined by the axis of rotation and by one of the positions corresponding to the image data.

27. In a mammography system of the type having an x-ray source that rotates in an arc about the breast to irradiate the breast from different positions on the arc, the arc having an axis of rotation and spanning a plane that intersects the breast, the improvement comprising:

a stationary x-ray detector for detecting x-ray radiation transmitted through the breast and for producing image data representative of the intensity of the radiation; and

a data processor for determining x-ray absorption points within the breast based upon an image data set having image data corresponding to positions along the arc, the processor having means for transforming the image data, at each of the positions, to a form representative of the expected intensity of x-ray radiation generated by the source at an offset position defined by the intersection between (a) a line in the plane that is substantially parallel to the detector, and (b) a line in the plane defined by the axis of rotation and by one of the positions corresponding to the image data.