Method for transmyocardial revascularization

• US 5,873,366 A
• Filed: 11/07/1996
• Issued: 02/23/1999
• Est. Priority Date: 11/07/1996
• Status: Expired due to Term

• Current Assignee: Marilyn M. Chou, Nicholas Chim
• Original Assignee: Marilyn M. Chou, Nicholas Chim
• Inventors: Chim, Nicholas, Chou, Marilyn M.
• Primary Examiner(s): Jaworski, Francis J.
• Application Number:
  US08/744,397
• Time in Patent Office: 838 Days
• Field of Search: 606/7, 606/12, 606/14-15, 606/19, 606/194, 604/4, 604/27, 604/53, 435/1.1, 435/1.2, 514/275, 128/898
• US Class Current: 128/898
• CPC Class Codes: A61B 18/24 with a catheter A61B18/26, A61B18/28 take precedence
• CPC Class Codes: A61B 2017/00247 Making holes in the wall of the heart, e.g. laser Myocardial revascularization
• CPC Class Codes: A61B 2017/22082 after introduction of a substance
• CPC Class Codes: A61B 2018/00392 Transmyocardial revascularisation

Abstract

A method for performing transmyocardial revascularization (TMR) uses a cardioplegic agent to briefly stop the heartbeat long enough to create 10 to 40 carefully placed transmyocardial blood flow channels using a laser. The cardioplegic agent used may be adenosine or an adenosine triphosphate-sensitive potassium channel opener, such as aprikalim, or a standard hyperkalemic cardioplegic agent. The temporarily induced motionlessness of the heart allows accurate and efficient placement of the blood flow channels, while the short duration of the cardioplegic effect obviates the need for cardiopulmonary bypass. The blood flow channels can be formed from the exterior or the interior of the heart. Preferably, the TMR procedure is performed using an infrared laser, such as a CO₂ laser with an articulated-arm waveguide or a pulsed Nd:YAG laser with a flexible fiberoptic delivery system, or a near infrared laser, such as a holmium:YAG or erbium laser with a flexible fiberoptic delivery system, because of their ability to efficiently ablate clearly defined passages through myocardial tissue without inducing significant thermal damage to the surrounding myocardium. The laser delivery device or a separate probe can be used to verify the depth of the blood flow channels and their connection with the ventricular chamber. The heart resumes beating spontaneously after reperfusion, with no need for defibrillation or cardioversion. The TMR procedure can be performed by a cardiac or thoracic surgeon using standard open-chest surgical techniques or using a minimally invasive surgical approach or by an interventional cardiologist using a percutaneous transluminal intravascular approach.

Claims

1. A method of performing transmyocardial revascularization on heart comprising the steps of:

(a) temporarily stopping the heart from beating by inducing a brief period of asystole with a duration of less than approximately one minute;

(b) creating at least one blood flow channel within a wall of the heart during said brief period of asystole, said at least one blood flow channel having a fluid connection with a chamber of the heart; and

(c) allowing the heart to resume beating.

2. The method of claim 1 wherein step (a) comprises infusing the heart with a cardioplegic agent having a short half life to induce a brief period of asystole with a duration of less than approximately one minute.

3. The method of claim 2 wherein said brief period of asystole has a duration of less than approximately twenty seconds.

4. The method of claim 2 wherein said brief period of asystole is induced by a bolus infusion of adenosine at a concentration sufficient to induce asystole in the heart.

5. The method of claim 4 wherein said brief period of asystole is induced by a bolus infusion of adenosine at a dosage of approximately 0.15-0.25 mg/kg.

6. The method of claim 2 further comprising the step of:

(d) probing said at least one blood flow channel during said period of asystole to verify the fluid connection between said at least one blood flow channel and the chamber of the heart.

7. The method of claim 1 wherein steps (a), (b) and (c) are performed without cardiopulmonary bypass.

8. The method of claim 1 wherein step (b) comprises creating a multiplicity of blood flow channels within the wall of the heart.

9. The method of claim 1 wherein step (b) comprises irradiating an exterior surface of the heart with laser energy to create said at least one blood flow channel within the wall of the heart.

10. The method of claim 1 wherein step (b) comprises irradiating an interior surface of the heart with laser energy to create said at least one blood flow channel within the wall of the heart.

11. The method of claim 1 wherein step (b) comprises irradiating a surface of the heart with laser energy delivered through a fiberoptic laser delivery device to create said at least one blood flow channel within the wall of the heart.

12. The method of claim 1 wherein step (b) comprises irradiating a surface of the heart with infrared laser energy to create said at least one blood flow channel within the wall of the heart.

13. The method of claim 12 wherein step (b) further comprises generating said infrared laser energy with a CO₂ laser.

14. The method of claim 1 wherein step (b) comprises irradiating a surface of the heart with near-infrared laser energy to create said at least one blood flow channel within the wall of the heart.

15. The method of claim 14 wherein step (b) further comprises generating said near-infrared laser energy with a holmium:

YAG laser.

16. The method of claim 1 wherein step (c) comprises reperfusing the heart with oxygenated blood to induce the heart to resume beating.

17. A method of performing transmyocardial revascularization on a heart comprising the steps of:

(a) temporarily stopping the heart from beating by infusing the heart with a cardioplegic agent having a short half life to induce a brief period of asystole which has a duration of less than approximately one minute;

(b) creating a multiplicity of blood flow channels within a wall of the heart by irradiating a surface of the heart with laser energy during said period of asystole, said blood flow channels having a fluid connection with a chamber of the heart; and

(c) reperfusing the heart with oxygenated blood to induce the heart to resume beating.

18. The method of claim 17 wherein said brief period of asystole is induced by a bolus infusion of adenosine at a concentration sufficient to induce asystole in the heart.

19. The method of claim 18 wherein said brief period of asystole is induced by a bolus infusion of adenosine at a dosage of approximately 0.15-0.25 mg/kg.

20. The method of claim 17 further comprising the step of:

(d) probing said blood flow channels during said period of asystole to verify the fluid connection between said blood flow channels and the chamber of the heart.

21. The method of claim 17 wherein said brief period of asystole has a duration of less than approximately twenty seconds.

22. The method of claim 18 wherein steps (a), (b) and (c) are performed without cardiopulmonary bypass.