Remotely programmable matrices with memories
First Claim
1. A combination of a matrix with memory, comprising:
- (A) a recording device, comprising memory means containing a data storage unit; and
(B) a matrix, wherein;
the matrix is either comprised of particles of a size such that at least one dimension is no more than 100 mm or the matrix is in the form of a container selected from the group consisting of vials, test tubes, culture dishes, vessels of a volume of about 100 ml or less, and microtiter plates or is in the form of a continuous surface that encases the recording device; and
the recording device, further comprises;
reaction verifying means, comprising a sensor means which senses an energy release during a reaction and generates an electrical signal in response thereto.
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Accused Products
Abstract
Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The data storage units are non-volatile antifuse memories or volatile memories, such as EEPROMS, DRAMS or flash memory. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for electronically tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, and other methods are also provided.
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Citations
31 Claims
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1. A combination of a matrix with memory, comprising:
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(A) a recording device, comprising memory means containing a data storage unit; and (B) a matrix, wherein; the matrix is either comprised of particles of a size such that at least one dimension is no more than 100 mm or the matrix is in the form of a container selected from the group consisting of vials, test tubes, culture dishes, vessels of a volume of about 100 ml or less, and microtiter plates or is in the form of a continuous surface that encases the recording device; and the recording device, further comprises; reaction verifying means, comprising a sensor means which senses an energy release during a reaction and generates an electrical signal in response thereto. - View Dependent Claims (2, 3, 4, 5, 6, 7, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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8. A method for drug delivery, to an animal, comprising:
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combining with a drug delivery device a combination of a matrix with memory with a biosensor, wherein;
the combination of the matrix with memory comprises;(A) a recording device, comprising a data storage unit; and (B) a matrix that is either; (i) comprised of particles of a size such that at least one dimension is no more than 100 mm;
or(ii) is in the form of a continuous surface that encases the recording device; and the recording device further comprises a sensor means that detects changes in an internal condition in the body of the animal and causes a record of such change to be recorded in the memory in the combination; introducing the resulting combined drug delivery device-matrix with memory combination-biosensor into the body of an animal monitoring changes in the internal condition in the body of the animal with a means that reads the memory in the combination; and adjusting the delivery of the drug as a function of the recorded change in the internal condition. - View Dependent Claims (9, 10, 11)
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Specification