Recombinant infectious bovine rhinotracheitis virus
First Claim
1. A live recombinant infectious bovine rhinotracheitis virus comprising a first and a second foreign DNA, each of which encodes a polypeptide of a RNA virus, inserted into an infectious bovine rhinotracheitis virus genome, wherein the first and the second foreign DNA are inserted into a non-essential region of the infectious bovine rhinotracheitis virus genome, which region is the same or different and is selected from the group consisting of the glycoprotein E(gpE) gene, the glycoprotein G(gpG) gene and the US2 gene.
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Abstract
The present invention provides recombinant infectious bovine rhinotracheitis (IBR) viruses useful in vaccines to protect bovines from diseases particular to them, including infectious bovine rhinotracheitis and bovine respiratory disease complex. The present invention further provides methods for distinguishing an animal vaccinated with a vaccine of the present invention from an animal infected with a naturally-occurring IBR virus. The present invention also provides isolated DNA encoding the gpE glycoprotein, the gpG glycoprotein, and US2 genes of an IBR virus. The present invention further provides homology vectors for producing recombinant IBR viruses.
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7 Claims
- 1. A live recombinant infectious bovine rhinotracheitis virus comprising a first and a second foreign DNA, each of which encodes a polypeptide of a RNA virus, inserted into an infectious bovine rhinotracheitis virus genome, wherein the first and the second foreign DNA are inserted into a non-essential region of the infectious bovine rhinotracheitis virus genome, which region is the same or different and is selected from the group consisting of the glycoprotein E(gpE) gene, the glycoprotein G(gpG) gene and the US2 gene.
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