(+) -.alpha.- (2,3-dimethoxyphenyl)-1-(2-(4-fluorephenyl) ethyl)-4-piepridinemethanol

• US 5,874,445 A
• Filed: 10/02/1997
• Issued: 02/23/1999
• Est. Priority Date: 06/01/1990
• Status: Expired due to Fees

• Current Assignee: Aventis Incorporated (Sanofi )
• Original Assignee: Merrell Pharmaceuticals Incorporated (Dow, Inc.)
• Inventors: Schmidt, Christopher J., Kane, John M., Carr, Albert A., Hay, David A.
• Primary Examiner(s): Mach, D. Margaret M.
• Application Number:
  US08/942,629
• Time in Patent Office: 509 Days
• Field of Search: 514/317
• US Class Current: 514/317
• CPC Class Codes: A61P 1/14 Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/20 Hypnotics; Sedatives
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 7/02 Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• CPC Class Codes: A61P 9/06 Antiarrhythmics
• CPC Class Codes: A61P 9/08 Vasodilators for multiple indications
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C07D 211/22 by oxygen atoms

Abstract

The present invention is directed to a new 5HT₂ antagonist, (+)-α-(2,3-dimethoxyphenyl)-1- 2-(4-fluorophenyl)ethyl!-4-piperidinemethanol, and its use in the treatment of a number of disease states.

Claims

1. A method for treating intermittent claudication comprising administering a therapeutic amount of (+)-alpha-(2,3-dimethoxyphenyl)-1- 2-(4-fluorophenyl)-ethyl!-4-piperdinemethanol or a pharmaceutically acceptable acid addition salt thereof to a patient in need of such therapy.