Fluorochemical solutions for the delivery of lipophilic pharmaceutical agents
First Claim
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1. A thermodynamically stable molecular solution providing enhanced bioavailability for lipophilic pharmaceutical agents, said molecular solution comprising:
- a liquid carrier comprising one or more physiologically acceptable lipophilic fluorochemicals comprising four or more carbon atoms and at least one nonfluorinated co-solvent; and
a pharmaceutically effective amount of at least one lipophilic pharmaceutical agent in said liquid carrier.
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Abstract
A thermodynamically stable molecular solution providing enhanced bioavailability for lipophilic pharmaceutical agents, comprising a liquid carrier comprising one or more physiologically acceptable lipophilic fluorochemicals, and a pharmaceutically effective amount of at least one lipophilic pharmaceutical agent in said liquid carrier to form a thermodynamically stable molecular solution, optionally also including a co-solvent for facilitating solubilization of the pharmaceutical agent. Methods of making and using the molecular solution are also disclosed.
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Citations
35 Claims
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1. A thermodynamically stable molecular solution providing enhanced bioavailability for lipophilic pharmaceutical agents, said molecular solution comprising:
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a liquid carrier comprising one or more physiologically acceptable lipophilic fluorochemicals comprising four or more carbon atoms and at least one nonfluorinated co-solvent; and a pharmaceutically effective amount of at least one lipophilic pharmaceutical agent in said liquid carrier. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 14)
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12. A method for preparing a thermodynamically stable molecular solution exhibiting enhanced bioavailability, said method comprising the steps of:
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providing a liquid carrier comprising one or more physiologically acceptable lipophilic fluorochemicals comprising four or more carbon atoms and at least one nonfluorinated co-solvent; and combining a pharmaceutically effective amount of at least one lipophilic pharmaceutical agent with said liquid carrier to form said thermodynamically stable molecular solution. - View Dependent Claims (13, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A method for delivering at least one lipophilic pharmaceutical agent to a physiologic target site, said method comprising the steps of:
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providing a thermodynamically stable molecular solution comprising at least one lipophilic pharmaceutical agent incorporated in a physiologically acceptable liquid carrier, said liquid carrier comprising one or more lipophilic fluorochemicals comprising four or more carbon atoms and at least one nonfluorinated co-solvent; and introducing a pharmaceutically effective amount of said thermodynamically stable molecular solution to a physiologic target site. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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Specification