Dry powder inhaler

• US 5,875,776 A
• Filed: 04/09/1996
• Issued: 03/02/1999
• Est. Priority Date: 04/09/1996
• Status: Expired due to Term

• Current Assignee: Abraxis Bioscience LLC (Bristol-Myers Squibb Company)
• Original Assignee: Vivorx Pharmaceuticals Incorporated (Bristol-Myers Squibb Company)
• Inventors: Vaghefi, Farid
• Primary Examiner(s): Lewis, Aaron J.
• Application Number:
  US08/629,605
• Time in Patent Office: 1,057 Days
• Field of Search: 128/203.12, 128/203.15, 128/203.21, 128/205.21, 604/58
• US Class Current: 128/203.15
• CPC Class Codes: A61M 11/02 operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised sprayers for horticulture A01G, A01H; killing insects A01M; air humidifying by nozzles F24F6/14, F24F6/18; cooling by spraying F28B, F28C
• CPC Class Codes: A61M 15/0031 by bursting or breaking the package, i.e. without cutting or piercing
• CPC Class Codes: A61M 15/0036 hollow piercing means
• CPC Class Codes: A61M 15/0045 using multiple prepacked dosages on a same carrier, e.g. blisters
• CPC Class Codes: A61M 15/0048 the dosages being arranged in a plane, e.g. on diskettes
• CPC Class Codes: A61M 15/0086 Inhalation chambers
• CPC Class Codes: A61M 15/02 with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/8225 using incorporated gas cartridges for the driving gas

Abstract

A dry powder inhaler includes a housing, a dosing cartridge, and a spacer. Within the housing are a source of pressurized gas, a pressure gauge, a metered valve controlled by a trigger, a safety valve, and an electrostatic charger also controlled by the trigger. The dosing cartridge contains individual doses in airtight cells with one or more openings, each covered by an airtight coversheet. The system uses gas pressure or a penetration device to rupture one of the airtight cells, suspending the powder and directing it to a spacer for subsequent inhalation. The electrostatic charger discharges on the spacer, establishing an electrostatic charge thereon. The spacer includes a non-stick lining. The housing is designed so that it can retract into the spacer.

Claims

1. A dry powder inhaler for use with a removable dosing cartridge, wherein said dosing cartridge includes a dry powder in a cell with one or more sealed openings, the dry powder inhaler comprising:

a housing adapted to removably receive a dosing cartridge, the housing defining three passages;

a first valve for controlling the flow of gas from the first passage to the second passage; and

a mouthpiece;

wherein

the first passage includes a connection adapted for connecting to a source of pressurized gas;

the second and third passages have a suspension system for separately connecting to and rupturing the sealed openings of a cell, and additionally for suspending a dry powder; and

the third passage is further connected to the mouthpiece.

2. A dry powder inhaler according to claim 1, wherein:

the second passage is adapted to have an entrance port for connecting to one of the sealed openings;

the third passage is adapted to have an exit port for connecting to another of the sealed openings; and

wherein said suspension system is comprised of said entrance and exit ports.

3. A dry powder inhaler according to claim 1, wherein said suspension system comprises one or more piercing needles for rupturing the sealed openings.

4. A dry powder inhaler according to claim 1, wherein said suspension system comprises:

a first hollow piercing needle adapted to pierce a sealed opening of the cell and connect the cell to the second passage; and

a second hollow piercing needle adapted to pierce a sealed opening of the cell and connect the cell to the third passage.

5. A dry powder inhaler according to claim 1, wherein the source of pressurized gas is a pressurized air cylinder.

6. A dry powder inhaler according to claim 5, wherein the first passage is connected to a pressure gauge.

7. A dry powder inhaler according to claim 6, wherein a passage further contains a safety valve that restricts the flow of gas upon the failure of the first valve to properly restrict the flow of gas.

8. A dry powder inhaler according to claim 1 wherein the inhaler additionally comprises

a housing with a trigger;

a hollow spacer connected to said housing, wherein said housing delivers the suspended dry powder into said spacer upon actuation of said trigger;

a mouthpiece connected to said spacer; and

an electrostatic charger adapted to be discharged within said spacer upon actuation of said trigger.

9. A dry powder inhaler according to claim 8, wherein said spacer includes an interior surface coated with a non-stick material.

10. A dry powder inhaler according to claim 9, wherein the non-stick material is Teflon.

11. A dry powder inhaler according to claim 8, wherein said housing is adapted to be retracted substantially into said hollow spacer.

12. A dry powder inhaler according to claim 8, wherein said spacer and said housing may be disconnected and reconnected.

13. A dry powder inhaler according to claim 8, further comprising an air inlet vent adapted to allow inhalation, but not exhalation, through said mouthpiece during operation of the inhaler.

14. A dry powder inhaler according to claim 13, wherein

said housing is adapted to be retracted substantially into said hollow spacer;

and

the interior surface of said spacer is coated with Teflon;

said spacer and said housing may be disconnected.

15. A dry powder cartridge inhaler, comprising:

the dry powder inhaler according to claim 1; and

a removable dosing cartridge wherein said dosing cartridge comprises a cartridge body defining at least one cell for containing a pharmaceutical, each of said cells having one or more openings, and further including one or more rupturable coversheets forming an airtight seal over the cell openings.

16. A dry powder cartridge inhaler according to claim 15, wherein:

said cartridge body further defines additional cells for containing a pharmaceutical, each additional cell having one or more openings; and

said coversheets form airtight seals over each of the additional cell openings.

17. A dry powder cartridge inhaler according to claim 16, wherein:

said cartridge body is disk-shaped;

the cells are arranged on said body in a rotationally symmetric pattern around an axis of rotational symmetry; and

each cell has an associated rotation stop included on said cartridge body.

18. A dry powder cartridge inhaler according to claim 15, further comprising:

a trigger connected to said housing;

a hollow spacer connected to said housing, wherein said trigger actuates said first valve causing the suspended dry powder to be delivered into said spacer, and said spacer connects said mouthpiece to the third passage; and

an electrostatic charger adapted to be discharged within said spacer upon actuation of said trigger.

19. A method for using a pressurized gas to dispense a dose of dry powder for inhalation from an airtight cell with one or more sealed openings, said method comprising:

providing an airtight cell with one or more sealed openings having a dose of dry powder therein;

rupturing at least one sealed opening in the airtight cell and blowing a pressurized gas into the cell, thereby pressurizing the cell and forming a suspension of the dry powder in the gas;

separately rupturing one of the sealed openings and allowing the pressurized suspension in the cell to flow out of the cell; and

directing the suspension for inhalation.

20. A method according to claim 19, wherein each rupture is caused by pressurized gas impinging on the sealed openings.

21. A method according to claim 19, wherein one or more piercing needles cause the ruptures.

22. A method according to claim 19, wherein the pressurized gas is provided from a pressurized air cylinder.

23. A method according to claim 19, wherein the airtight cell is formed within a dosing cartridge, the dosing cartridge including a plurality of airtight cells.

24. A method according to claim 19, wherein the flow is directed into a chamber for inhalation, and further comprising the step of establishing an electrostatic charge within the chamber.

25. A method according to claim 24, wherein each rupture is caused by pressurized gas impinging on the sealed openings.

26. A method according to claim 24, wherein one or more piercing needles cause the ruptures.

27. A method according to claim 24, wherein the pressurized gas is provided from a pressurized air cylinder;

and the airtight cell is formed within a dosing cartridge, said dosing cartridge further comprising a plurality of airtight cells;

said method further comprising venting the chamber to allow in-flowing air during inhalation.