Methods and apparatus for blood speckle detection in an intravascular ultrasound imaging system

• US 5,876,343 A
• Filed: 09/23/1997
• Issued: 03/02/1999
• Est. Priority Date: 09/23/1997
• Status: Expired due to Term

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Limited (Boston Scientific Corporation), Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Inventors: Teo, Tat-Jin
• Primary Examiner(s): Jaworski, Francis J.
• Application Number:
  US08/936,043
• Time in Patent Office: 525 Days
• Field of Search: 600/437, 600/443, 600/447, 600/451-458, 600/467, 600/463, 128/916, 382/6
• US Class Current: 600/443
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: G01S 15/895 characterised by the transmitted frequency spectrum
• CPC Class Codes: G01S 15/8979 Combined Doppler and pulse-echo imaging systems
• CPC Class Codes: G01S 7/52036 using analysis of echo signal for target characterisation
• CPC Class Codes: G01S 7/52046 Techniques for image enhancement involving transmitter or receiver image enhancement by image data processing G06T5/00

Abstract

Methods and apparatus for blood speckle detection for enhanced intravascular ultrasound imaging. The present invention utilizes the fact that the energy scattering strength from blood exhibits a high frequency dependency, while the scattering strength from tissue lacks a strong frequency dependency. In specific embodiments, the present invention may provide a particularly simple and useful solution for addressing the problem of blood speckle in intravascular ultrasound imaging, especially in situations where the blood may have a scattering strength similar to that of tissue and/or where the blood is moving slowly or not at all.

Claims

1. A method of distinguishing tissue from blood in an intravascular ultrasound blood vessel image, said method comprising the steps of:

illuminating an intravascular target with ultrasonic RF energy to generate ultrasonic echoes from said intravascular target;

transforming the ultrasonic echoes from the intravascular target into a received RF signal;

performing spectral analysis on at least a portion of said received RF signal to provide intensity information on the spectrum of said received RF signal, said information including a first intensity strength at a high frequency within said spectrum and a second intensity strength at a low frequency within said spectrum;

comparing said first intensity strength and said second intensity strength;

determining that said intravascular target is tissue if said first intensity strength and said second intensity strength are approximately equal and that said intravascular target is blood if said first intensity strength is greater than said second intensity strength, wherein said determining step takes into account tissue and blood backscatter strength sensitivities at said high and low frequencies.

2. The method of claim 1 wherein said step of performing spectral analysis is achieved by performing a complete Fourier analysis on said received RF signal such that said information provided is for the entire spectrum.

3. The method of claim 2 wherein a transducer used for said illumination step has known and sufficiently high detection sensitivities at both said high and low frequencies and wherein said low and high frequencies are selected to be between a low -3 dB frequency and a high -3 dB frequency of said transducer.

4. The method of claim 1 further comprising the step of:

selecting a narrowband high frequency channel containing said high frequency and a narrowband low frequency channel containing said low frequency.

5. The method of claim 4 wherein a transducer used for said illumination step has known and sufficiently high detection sensitivities at both said narrowband high and low frequency channels, and wherein said narrowband high frequency channel and said narrowband low frequency channel are selected to be between a low -3 dB frequency and a high -3 dB frequency of said transducer.

6. The method of claim 4 wherein a transducer used for said illumination step has known and sufficiently high detection sensitivities at both said narrowband high and low frequency channels, and wherein said narrowband high frequency channel and said narrowband low frequency channel are selected to be between a center frequency and a high -3 dB frequency of said transducer.

7. The method of claim 1 wherein said step of performing spectral analysis is achieved by filtering at said high frequency and at said low frequency.

8. The method of claim 7 wherein said filtering is performed by using respectively appropriate sets of filter coefficients stored in a memory such that said information provided is for said high frequency and for said low frequency.

9. The method of claim 8 wherein said filtering is performed using a look-up table as said memory.

10. The method of claim 7 wherein said filtering is performed by using hardware bandpass filters for said high frequency and for said low frequency.

11. The method of claim 1 wherein said illuminating step is performed with a transducer having a center frequency and a bandwidth of about 40-60% of said center frequency, wherein said high frequency is a frequency having a corresponding wavelength that is greater than the typical diameter of blood cells.

12. The method of claim 1 further comprising the steps of:

assigning said intravascular target a selected first shade if said first intensity strength and said second intensity strength are determined to be approximately equal and a selected second shade if said first intensity strength is determined to be greater than said second intensity strength; and

providing said intravascular ultrasound blood vessel image with tissue having said selected first shade and blood having said selected second shade on a display.

13. The method of claim 1 wherein said selected second shade is selected such that said blood is suppressed or removed from said intravascular ultrasound blood vessel image on said display.

15. The method of claim 1 wherein a transducer used for said illumination steps has known and sufficiently high detection sensitivities at both said high and low frequencies, and wherein said high frequency is selected to be between a center frequency and a high -3 dB frequency of said transducer, and said low frequency is selected to be between the center frequency and a low -3 dB frequency of said transducer.

16. The method of claim 15 further comprising the steps of:

assigning said portions of said subtracted image frame that are not cancelled-out a selected shade; and

providing said intravascular ultrasound blood vessel image with blood having said selected shade on a display, said selected shade being different from other shades for non-blood in said display.

17. The method of claim 15 further comprising the steps of:

providing said intravascular ultrasound blood vessel image on said display such that said portions of said subtracted image frame that are not cancelled-out are suppressed or removed from said intravascular ultrasound blood vessel image.

14. A method of distinguishing tissue from blood in an intravascular ultrasound blood vessel image, said method comprising the steps of:

illuminating an intravascular target with ultrasonic RF energy at a first frequency to generate ultrasonic echoes from said intravascular target to form a first image frame;

illuminating said intravascular target with ultrasonic RF energy at a second frequency to generate ultrasonic echoes from said intravascular target to form a second image frame, wherein said first and second image frames are successive in time and wherein one of said first and second frequencies is a low frequency and another one of said first and second frequencies is a high frequency;

subtracting said first and second image frames to obtain a subtracted image frame;

determining that portions of said subtracted image frame that are substantially cancelled-out are tissue and that portions of said subtracted image frame that are not cancelled-out are blood, wherein said determining step takes into account tissue and blood backscatter strength sensitivities at said high and low frequencies.

18. Apparatus for an ultrasonic blood vessel imaging system comprising:

a transducer having a frequency bandwidth including known and sufficiently high strength sensitivities at a first frequency and a second frequency, said transducer obtaining echoes from an intravascular target using ultrasounds transmitted at said first and said second frequencies to form an intravascular image, wherein said first and second frequencies are between a -3 dB low frequency and a -3 dB high frequency of said transducer;

a signal processing device capable of being coupled to said transducer and to a display for displaying said intravascular image;

a computer-readable medium storing a computer-readable program, said computer-readable medium coupled to be read by said signal processing device, said computer-readable program for comparing a first intensity strength for echoes from ultrasound at said first frequency with a second intensity strength for echoes from ultrasound at said second frequency to detect blood speckle in said intravascular image.

19. The apparatus of claim 18 wherein said computer-readable program compares said first and second intensity strengths for the same image frame.

20. The apparatus of claim 18 wherein said computer-readable program compares said first intensity strength with said second intensity strength by subtracting a first image frame obtained from echoes from ultrasound at said first frequency with a second image frame obtained from echoes from ultrasound at said second frequency to provide a subtracted image frame, said second image frame and said first image frame are successive image frames, said subtracted image frame including portions of said subtracted image frame that are not cancelled-out, said portions being deleted from or distinctly shaded in said intravascular image on said display.