Method for vascular impedance measurement

• US 5,876,347 A
• Filed: 09/23/1997
• Issued: 03/02/1999
• Est. Priority Date: 12/28/1990
• Status: Expired due to Term

• Current Assignee: Regents of The University of Minnesota (University of Minnesota)
• Original Assignee: Regents of The University of Minnesota (University of Minnesota)
• Inventors: Cohn, Jay N., Finkelstein, Stanley M., Chesney, Charles F.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): SCHAETZLE, KENNEDY
• Application Number:
  US08/935,568
• Time in Patent Office: 525 Days
• Field of Search: 600/485, 600/481, 600/504, 600/505, 600/526, 128/920
• US Class Current: 600/485
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: G09B 23/28 for medicine
• CPC Class Codes: Y10S 128/92 Computer assisted medical diagnostics

Abstract

A vascular impedance measurement instrument includes a transducer to obtain a digitized arterial blood pressure waveform. The digitized data is used to determine cardiac output, and to subsequently obtain measurements of impedance parameters using the modified Windkessel model of the arterial system. The instrument is used as an aid in diagnosing, treating and monitoring patients with cardiovascular disease.

Claims

1. A method for measuring vascular impedance properties from the blood pressure waveform of a patient, the waveform containing heart beat signals, comprising the steps of:

measuring and digitizing an arterial blood pressure of a patient to produce a series of digitized data samples representing a waveform of the arterial blood pressure of the patient, the waveform containing a heart beat signal;

determining an ejection time of the heart of the patient from the heart beat signal contained in the data samples;

processing the data samples to determine a mean arterial pressure of the patient;

processing said ejection time and other patient data to determine a cardiac output measurement value for the patient from at least said ejection time and other patient data; and

processing the data samples and the cardiac output value and mean arterial pressure to determine for the patient one or more parameters of a vascular impedance model, the parameters being measures of vascular impedance properties.

2. A method according to claim 1 further wherein the measures of vascular impedance properties include a measure of compliance of the patient'"'"'s blood vessels.

3. A method according to claim 1 further wherein the measures of vascular impedance properties include a measure of resistance of the patient'"'"'s blood vessels to the flow of blood.

4. A method for measuring vascular impedance properties from the blood pressure waveform of a patient, comprising the steps of:

obtaining a digital representation of an arterial blood pressure waveform of a patient;

processing the digital representation to determine a cardiac output value for the patient; and

processing the digital representation and the cardiac output value to determine for the patient one or more measures of vascular impedance properties.