Pacemaker system with peltier cooling of A-V node for treating atrial fibrillation

• US 5,876,422 A
• Filed: 07/07/1998
• Issued: 03/02/1999
• Est. Priority Date: 07/07/1998
• Status: Expired due to Fees

• Current Assignee: Vitatron Medical BV
• Original Assignee: Vitatron Medical BV
• Inventors: van Groeningen, Christianus J. J. E.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): SCHAETZLE, KENNEDY
• Application Number:
  US09/111,320
• Time in Patent Office: 238 Days
• Field of Search: 607/9, 607/3, 607/14, 607/96, 607/99, 606/21, 606/23, 606/22, 606/25, 606/26
• US Class Current: 607/3
• CPC Class Codes: A61F 2007/126 for invasive application, e.g. for introducing into blood vessels
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions

Abstract

There is provided a cardiac pacing system for dealing with dangerous atrial arrhythmias, wherein when an episode of such an arrhythmia is detected, the system operates to cool the A-V node so as to reversibly block conduction of the atrial excitations through to the ventricle, permitting uninterrupted asynchronous ventricular pacing during the episode. The system provides for an atrial lead having a Peltier element positioned toward its distal end, such that when the atrial lead distal end is affixed to the atrial heart wall, the cooling element is proximate to the A-V node. Upon detection of a dangerous atrial episode, the Peltier element is energized to cool the A-V node to point of effective block, and the pacemaker switches to asynchronous pacing. The atrial signals are continually monitored, and when the arrhythmia terminates on its own and a normal sinus rhythm is restored, the cooling is stopped, permitting the atrial excitations to be transferred through the A-V node and allowing a return of the pacemaker to a synchronous pacing mode.

Claims

1. A pacing system for pacing a patient'"'"'s heart, having pace pulse means for generating and delivering pacing pulses to at least the patient'"'"'s ventricle, sensing means for sensing atrial and ventricular natural beats, and mode means for controlling the mode of pacing, said mode control means normally controlling said pacemaker to pace the patient'"'"'s ventricle synchronously with respect to sensed atrial intrinsic beats in the absence of sensed intrinsic ventricular beats, comprising:

arrhythmia means for detecting from sensed atrial beats when the patient has an episode of a dangerous atrial arrhythmia;

cooling means for lowering the temperature of the patient'"'"'s A-V node so as produce a state of reversible A-V block; and

temperature control means for enabling said cooling means to cool said A-V node whenever a said episode is detected, thereby blocking condition through the patient'"'"'s A-V node; and

said mode means comprising switching means for switching said pacemaker to an asynchronous ventricular pacing mode whenever a said episode is detected.

2. The pacing system as described in claim 1, wherein said arrhythmia means comprises episode end means for determining the end of a said episode, and said mode means comprises means for switching said pacemaker to a synchronous ventricular pacing mode when a said episode end is determined.

3. The pacing system as described in claim 2, wherein said temperature control means comprises means for disabling said cooling means whenever a said end is detected.

4. The pacing system as described in claim 3, wherein said temperature control means comprises limit means for limiting the cooling of said A-V node to a predetermined temperature.

5. The pacing system as described in claim 1, wherein said cooling means comprises a Peltier element and means for positioning said Peltier element proximate to the patient'"'"'s A-V node.

6. The pacing system as described in claim 5, wherein said cooling means comprises current drive means for driving said Peltier element with current so as to produce cooling or heating.

7. The pacing system as described in claim 1, comprising an atrial lead carrying a Peltier element, said lead having a screw-in fixation element at its distal end.

8. A method of sensing and responding to atrial arrhythmias, comprising:

detecting an episode of an atrial arrhythmia in a patient;

initiating cooling proximate to the patient'"'"'s A-V node, and cooling said node sufficiently to reversibly block conduction therethrough;

pacing the patient'"'"'s ventricle asynchronously during said episode;

continually monitoring atrial signals while said node is blocked, and determining when said episode has terminated; and

in response to a determined termination of a said episode, stopping cooling of said A-V node, and pacing said patient on demand.

9. The method as described in claim 8, comprising monitoring ventricular excitations after initiating cooling of the A-V node, determining when conduction of signals through said A-V node has stopped and block has been achieved, and controlling said cooling sufficient to maintain A-V block as long as said episode continues.

10. A pacing system for pacing a patient, having pace pulse means for generating and delivering pacing pulses to at least the patient'"'"'s ventricle, sensing means for sensing atrial and ventricular natural beats, and mode control means for controlling the mode of pacing the patient'"'"'s ventricle, comprising:

means for detecting from sensed atrial beats when the patient has a dangerous atrial arrhythmia;

said mode control means having means for controlling said pacemaker to operate in an asynchronous ventricular pacing mode when said dangerous atrial arrhythmia is detected; and

block means for reversibly blocking conduction through the patient'"'"'s A-V node during a said dangerous atrial arrhythmia.

11. The system as described in claim 10, wherein said block means comprises cooling means for cooling the patient'"'"'s A-V node to a point of reversible A-V block.

12. The system as described in claim 11, wherein said cooling means comprises a Peltier element and drive means for driving said Peltier element to control its cooling operation.

13. The system as described in claim 10, wherein said mode control means has synchronous means for normally controlling said pacemaker to pace the patient'"'"'s ventricle synchronously with respect to sensed atrial natural beats in the absence of natural ventricular beats, and switching means for switching operation to said asynchronous mode whenever a said dangerous atrial arrhythmia is present.

14. The system as described in claim 10, wherein said block means comprises cooling means for cooling the patient'"'"'s heart in the vicinity of the AV node, thereby reversibly blocking conduction through said AV node for the duration of said cooling.

15. The system as described in claim 14, providing heat transfer means for transferring heat generated as a by-product of said cooling away from the vicinity of the AV node.

16. The system as described in claim 15, comprising a pacemaker encased in a can, and wherein said heat transfer means comprises means for transferring said heat to said pacemaker can.