Liposome preferentially traveling to cardiac and skeletal muscles
First Claim
1. A liposome which preferentially travels to cardiac and skeletal muscles, comprising a phosphatide chemically linked to a member selected from the group consisting of carnitine, aminocarnitine and cysteic acid.
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Accused Products
Abstract
Carnitine, aminocarnitine and cysteic acid serve as carriers to bring pharmaceutically active compounds to desired sites in the body, e.g. skeletal muscle or the heart. The pharmaceutically active compound can be a protease inhibitor, a cardioactive drug for combating arrythmia, etc. The linkage is chemical through one or more alcohol, carboxyl or amine groups using reagents such as glutaraldehyde, dicarboxylic acid anhydrides and acid halides and carbodiimides. Carnitine derivatives are also incorporated into liposomes which are then used as carriers of active pharmaceutical agents.
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Citations
6 Claims
- 1. A liposome which preferentially travels to cardiac and skeletal muscles, comprising a phosphatide chemically linked to a member selected from the group consisting of carnitine, aminocarnitine and cysteic acid.
Specification