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Treatment for atherosclerosis and other cardiovascular and inflammatory diseases

  • US 5,877,203 A
  • Filed: 10/17/1996
  • Issued: 03/02/1999
  • Est. Priority Date: 10/30/1992
  • Status: Expired due to Term
First Claim
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1. A method for treating inflammatory diseases by VCAM-1 expression in human cells comprising administering an effective amount of a dithiocarbamate of the formula:

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    space="preserve" listing-type="equation">R.sup.1 SC(S)NR.sup.2 R.sup.3wherein R1 is H, sodium, potassium, or NR4 R5 R6 R7, wherein R4, R5, R6, and R7 are independently hydrogen, C1-6 linear, branched, or cyclic alkyl, hydroxy(C1-6)alkyl, or aryl, andR2 and R3 are independently C1-10 linear, branched or cyclic alkyl;

    --(CHOH)n (CH2)n OH, wherein n is independently 0-6;

    --(CH2)n CO2 R1, --(CH2)n CO2 R8 ;

    hydroxy(C1-6)alkyl--, or R2 and R3 together constitute a bridge of the formula --(CH2)m --, wherein m is 3-6, and wherein R8 is alkyl, aryl, alkylaryl, or aralkyl or its pharmaceutically acceptable salt.

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