Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
First Claim
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1. A method for treating inflammatory diseases by VCAM-1 expression in human cells comprising administering an effective amount of a dithiocarbamate of the formula:
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space="preserve" listing-type="equation">R.sup.1 SC(S)NR.sup.2 R.sup.3wherein R1 is H, sodium, potassium, or NR4 R5 R6 R7, wherein R4, R5, R6, and R7 are independently hydrogen, C1-6 linear, branched, or cyclic alkyl, hydroxy(C1-6)alkyl, or aryl, andR2 and R3 are independently C1-10 linear, branched or cyclic alkyl;
--(CHOH)n (CH2)n OH, wherein n is independently 0-6;
--(CH2)n CO2 R1, --(CH2)n CO2 R8 ;
hydroxy(C1-6)alkyl--, or R2 and R3 together constitute a bridge of the formula --(CH2)m --, wherein m is 3-6, and wherein R8 is alkyl, aryl, alkylaryl, or aralkyl or its pharmaceutically acceptable salt.
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Abstract
Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty restenosis, coronary artery diseases, and angina, as well as noncardiovascular inflammatory diseases that are mediated by VCAM-1.
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Citations
14 Claims
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1. A method for treating inflammatory diseases by VCAM-1 expression in human cells comprising administering an effective amount of a dithiocarbamate of the formula:
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space="preserve" listing-type="equation">R.sup.1 SC(S)NR.sup.2 R.sup.3wherein R1 is H, sodium, potassium, or NR4 R5 R6 R7, wherein R4, R5, R6, and R7 are independently hydrogen, C1-6 linear, branched, or cyclic alkyl, hydroxy(C1-6)alkyl, or aryl, and R2 and R3 are independently C1-10 linear, branched or cyclic alkyl;
--(CHOH)n (CH2)n OH, wherein n is independently 0-6;
--(CH2)n CO2 R1, --(CH2)n CO2 R8 ;
hydroxy(C1-6)alkyl--, or R2 and R3 together constitute a bridge of the formula --(CH2)m --, wherein m is 3-6, and wherein R8 is alkyl, aryl, alkylaryl, or aralkyl or its pharmaceutically acceptable salt. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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Specification