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Tissue chromophore measurement system

  • US 5,879,294 A
  • Filed: 06/28/1996
  • Issued: 03/09/1999
  • Est. Priority Date: 06/28/1996
  • Status: Expired due to Term
First Claim
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1. A measurement system for determining a relative concentration of a first form of a chromophore in a tissue sample, said chromophore comprising at least a first form and a second form, comprising:

  • (a) means for irradiating said tissue sample with light at a plurality of wavelengths within a wavelength range within which the first and second forms of the chromophore provide an overlapping spectral response, such that spectral data is emitted from said tissue;

    (b) means for detecting the spectral data emitted from said tissue;

    (c) means for determining a first 2d derivative spectrum value of the spectral data at a first wavelength within said wavelength range at which the first 2d derivative spectrum value varies with the relative concentration of the first form of the chromophore;

    (d) means for determining a second 2d derivative spectrum value of the spectral data at a second wavelength within said wavelength range at which the first 2d derivative spectrum value varies with the relative concentration of the first form of the chromophore;

    (e) means for deriving a scaled, 2d derivative spectrum value from information comprising the first and second 2d derivative spectrum values; and

    (f) means for storing a correlation which provides the relative chromophore concentration as a function of the scaled, 2d derivative spectrum value; and

    (g) means for determining the relative concentration of the first form of the chromophore in the tissue sample from information comprising the scaled, 2d derivative spectrum value and the correlation.

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