Nonpolymeric epoxy compounds for cross linking biological tissue and bioprosthetic grafts prepared thereby
First Claim
1. A biological tissue graft comprising a collagen-containing tissue which has been cross linked by immersion in a solution comprising a fixative compound having the general formula:
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space="preserve" listing-type="equation">R.sub.1 --CH.sub.2 --O--X--O--CH.sub.2 --R.sub.2wherein, the molecular backbone X is an aliphatic hydrocarbon having a straight carbon chain consisting of at least four and no more than five carbon atoms bonded directly to one another, said straight carbon chain being devoid of side branches and having terminal carbon atoms at either end thereof, the terminal carbon atoms at the ends of said straight carbon chain being bonded to the oxygen atoms shown in general formula, wherein at least one of the terminal groups R1, R2 is an epoxy group and the other of the such terminal groups R1, R2 is either a) an epoxy group, or b) an aldehyde group,said solution being substantially devoid of additional chemical compounds that react with collagen or with said fixative compound during cross linking.
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Accused Products
Abstract
A solution containing a nonpolymeric epoxy compound for cross linking biological tissues and bioprosthetic materials prepared thereby. The nonpolymeric epoxy compound has the general structural formula:
R.sub.1 --CH.sub.2 --O--X--O--CH.sub.2 --R.sub.2
wherein, X is a straight chain aliphatic hydrocarbon having at least four (4) and no more than five (5) carbon atoms bonded directly to one another, said straight chain aliphatic hydrocarbon being devoid of side branches and having terminal carbon atoms at either end thereof, the terminal carbon atoms at the ends of said straight chain aliphatic hydrocarbon being bonded to the oxygen atoms shown in the foregoing general formula, wherein at least one of the terminal groups R1, or R2 is an epoxy group and the other of said terminal groups R1 or R2 is either a) an epoxy group, or b) an aldehyde group. One preferred crosslinking agent of the above general formula is 1,4, butanediol diglycidyl ether. The solution of the present invention contains no other chemical compounds which would react with either collagen or with the crosslinking agent of the present invention.
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Citations
13 Claims
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1. A biological tissue graft comprising a collagen-containing tissue which has been cross linked by immersion in a solution comprising a fixative compound having the general formula:
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space="preserve" listing-type="equation">R.sub.1 --CH.sub.2 --O--X--O--CH.sub.2 --R.sub.2wherein, the molecular backbone X is an aliphatic hydrocarbon having a straight carbon chain consisting of at least four and no more than five carbon atoms bonded directly to one another, said straight carbon chain being devoid of side branches and having terminal carbon atoms at either end thereof, the terminal carbon atoms at the ends of said straight carbon chain being bonded to the oxygen atoms shown in general formula, wherein at least one of the terminal groups R1, R2 is an epoxy group and the other of the such terminal groups R1, R2 is either a) an epoxy group, or b) an aldehyde group, said solution being substantially devoid of additional chemical compounds that react with collagen or with said fixative compound during cross linking. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification