Measuring apparatus for intraocular substance employing light from eyeball
First Claim
1. Apparatus for determining concentration of an intraocular substance in an eyeball, comprising:
- an excitation optical system having a monochromated or single-wavelength excitation light beam, wherein said excitation light system is positioned relative to said eyeball so that said excitation light beam is not incident upon an iris in the eyeball, anda photoreceiving optical system having an optical element and a photodetector, wherein the optical element guides a plurality of measuring light components being emitted simultaneously from a plurality of locations within the eyeball, wherein the photodetector is selective for said plurality of measuring light components, wherein each of said measuring light components has spectral intensities, and wherein said concentration ofihe intraocular substance is afinction of said spectral intensities detected by said photodetector.
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Abstract
Relative directions of excitation and photoreceiving optical systems are so set that an angle formed by optical axes thereof in the air is 14°, and an eyeball is fixed in such a direction that its ocular axis divides the angle formed by the optical axes into two equal parts. On a light incidence side of a one-dimensional solid-state image pickup device of the photoreceiving optical system, a slit is arranged for inputting measuring light components generated from portions of the eyeball having different depth positions on an excitation light beam in photoelectric conversion elements of different positions of the image pickup device. The measuring light components generated from the respective portions of the eyeball parallel to the optical axis are incident upon the one-dimensional solid-state image pickup device through the slit and simultaneously detected, so that the positions of the photoelectric conversion elements and measuring light component generating positions at the eyeball correspond to each other.
44 Citations
46 Claims
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1. Apparatus for determining concentration of an intraocular substance in an eyeball, comprising:
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an excitation optical system having a monochromated or single-wavelength excitation light beam, wherein said excitation light system is positioned relative to said eyeball so that said excitation light beam is not incident upon an iris in the eyeball, and a photoreceiving optical system having an optical element and a photodetector, wherein the optical element guides a plurality of measuring light components being emitted simultaneously from a plurality of locations within the eyeball, wherein the photodetector is selective for said plurality of measuring light components, wherein each of said measuring light components has spectral intensities, and wherein said concentration ofihe intraocular substance is afinction of said spectral intensities detected by said photodetector. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. Apparatus for determining concentration of an intraocular substance in an eyeball that has an ocular as a function of intensities of spectral components of light emanating from the eyeball, said apparatus comprising:
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a monochronated light source that is positionable adjacent an eyeball in a manner that propagates a monochromatic light beam into the eyeball along a first optical axis that is oriented at an angle to said ocular axis such that said first optical axis and said ocular axis are not congruent with each other, a photodectorpositionable adjacent the eyeball and having a plurality of photoelectric elements that are capable of producing singal indicatives of intensity of light that is incident on said photoelectric elements, said photoelectric elements being positioned in a spaced array extending perpendicular to a second optical axis such that said second optical axis extends into the eyeball to intersect said first optical axis, said second optical axis also being at an angle to said ocular axis and in a common plane that includes said first optical axis and said ocular axis such that said ocular axis is positioned between said first optical axis and said second optical axis, said array of photoelectric elements also being positioned in said plane and having a pitch; a plurality of optical guiide elements positionable in a spaced array between the photodetector and the eyeball on said second optical axis, parallel to said array of photoelectric elements, and with a pitch that matches the pitch of the photoelectric elements such that each optical guide element is positioned to direct light emanating from the eyeball parallel to the second optical axis into one of said photoelectric elements; and a spectroscope positionable on said second optical axis between the photodetector and the eyeball said spectroscope being capable of separating said light emanating from the eyeball into spectral components such that signals produced by said photoelectric elements are indicative of intensities of spectral components of light emanating from the eyeball.
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29. A method for determining concentration of a substance in a body of a subject, said method comprising:
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(a) irradiating an eye of the subject with an excitation light beam, said excitation light beam being incident upon a plurality of locations within an anterior portion of the eye and reemerging from the eye as a plurality of measuring light components; (b) passing said plurity of measuring light components through an optical element to guide each of said measuring light components to a corresponding position on a photodetector; (c) measuring a spectral intensity of each of the measuring light components passing through the optical element and producing electrical signals representative of said measured intensity; and (d) calculating the concentration of the substance based on the measured electrical signals. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46)
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Specification