Polyurethane/polyurea compositions containing silicone for biosensor membranes

• US 5,882,494 A
• Filed: 08/28/1995
• Issued: 03/16/1999
• Est. Priority Date: 03/27/1995
• Status: Expired due to Term

• Current Assignee: Minimed, Inc. (Medtronic Plc)
• Original Assignee: Minimed, Inc. (Medtronic Plc)
• Inventors: Van Antwerp, William P.
• Primary Examiner(s): Marquis, Melvyn I.
• Application Number:
  US08/519,693
• Time in Patent Office: 1,296 Days
• Field of Search: 204/403, 128/632, 528/28, 528/29, 528/41
• US Class Current: 600/347
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: C08G 18/4833 Polyethers containing oxyethylene units
• CPC Class Codes: C08G 18/61 Polysiloxanes
• CPC Class Codes: C08G 18/6674 with compounds of group C08G18/3203
• CPC Class Codes: C08G 77/458 containing polyurethane sequences
• CPC Class Codes: C08J 2383/02 Polysilicates
• CPC Class Codes: C08J 5/2287 After-treatment
• CPC Class Codes: C12Q 1/002 Electrode membranes
• CPC Class Codes: C12Q 1/006 for glucose

Abstract

A homogenous polymer composition useful as a membrane for biosensors is disclosed. The polymer composition comprises the reaction products of a diisocyanate, a hydrophilic diol or diamine, and a silicone material. An aliphatic diol or diamine may also be included. Membranes prepared from the composition allow for increasing oxygen permeability and decreased analyte permeability (e.g. glucose). They also possess the necessary physical properties of an outer polymeric biosensor membrane.

Claims

1. An implantable biosensor for measuring the reaction of an analyte and oxygen, said biosensor having a biocompatible membrane for controlling the permeability of analyte and oxygen to the biosensor elements, said membrane comprising a homogenous polymer composition comprising the reaction products of at least one diisocyanate, at least one hydrophilic diol or diamine, and at least one silicone material.

2. The biosensor of claim 1, wherein the analyte comprises glucose.

3. The homogenous polymer composition of claim 1, further comprising at least one aliphatic diol or diamine added to the reaction.

4. The biosensor of claim 3, wherein the polymer comprises from about 50 mole percent diisocyanate, about 5 to about 45 mole percent hydrophilic diol or diamine, about 5 to about 45 mole percent aliphatic diol or diamine, and about 5-40 mole percent silicone material.

5. An implantable biosensor according to claim 1, wherein said polymer composition comprises at least one diisocyanate selected from the group consisting of hexamethylene diisocyanate, isophorone diisocyanate, 4,4'"'"'-methylenebis(cyclohexyl isocyanate) and an aromatic diisocyanate.

6. A homogeneous polymer composition in accordance with claim 3, wherein the aliphatic diol is selected from the group consisting of ethylene glycol, propylene glycol and 1,3 propane diol and the diamine is 1,3 diaminopropane.

7. An implantable biosensor according to claim 1, wherein said polymer composition comprises at least one silicone material selected from the group consisting of a polydimethyl siloxane polymer, a generic bifunctional terminated siloxane, an aminopropyl dimethyl terminated siloxane, a carboxypropyldimethyl terminated siloxane and a carbinol terminated siloxane.