Percutaneous absorption preparation

• US 5,882,675 A
• Filed: 03/07/1997
• Issued: 03/16/1999
• Est. Priority Date: 03/09/1996
• Status: Expired due to Fees

• Current Assignee: Nitto Denko Corporation
• Original Assignee: Nitto Denko Corporation
• Inventors: Tokuda, Shoichi, Ninomiya, Kazuhisa, Fukushima, Yasuhiro
• Primary Examiner(s): BROUILLETTE, D GABRIELLE
• Application Number:
  US08/812,545
• Time in Patent Office: 739 Days
• Field of Search: 424/448, 424/449, 424/489
• US Class Current: 424/448
• CPC Class Codes: A61K 47/14 Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/7061 Polyacrylates
• CPC Class Codes: A61L 15/58 Adhesives
• CPC Class Codes: C08L 33/06 of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical

Abstract

The present invention provides a percutaneous absorption preparation which has excellent pressure-sensitive adhesive characteristics and exerts excellent percutaneous absorption property. A crosslinking agent is added to a solution of an acrylic copolymer prepared by copolymerizing a (meth)acrylic acid alkyl ester with a functional monomer, and the acrylic copolymer is partially crosslinked. A composition containing the crosslinked acrylic copolymer is pulverized to prepare a pressure-sensitive adhesive solution comprised of the acrylic copolymer containing crosslinked acrylic copolymer particles. Thereafter, a drug for percutaneous absorption use, a percutaneous penetration enhancer are added to the pressure-sensitive adhesive solution, thereby producing the percutaneous absorption preparation.

Claims

1. A percutaneous absorption preparation comprising a backing having formed on one side thereof a pressure-sensitive adhesive layer containing a drug for percutaneous absorption use,

wherein the pressure-sensitive adhesive layer contains

(A) an acrylic copolymer which is an acrylic pressure-sensitive adhesive and

(B) crosslinked acrylic copolymer particles prepared from an acrylic pressure-sensitive adhesive, wherein the crosslinked particles have a size of from about 0.05 to about 20 microns and are present in an amount of from about 70 to about 400 parts by weight of the acrylic copolymer.

2. The percutaneous absorption preparation of claim 1, wherein the crosslinked acrylic copolymer particles are those prepared by subjecting an acrylic copolymer to crosslinking and pulverization.

3. The percutaneous absorption preparation of claim 1, wherein the pressure-sensitive adhesive layer further contains a percutaneous penetration enhancer.

4. The percutaneous absorption preparation of claim 1, wherein the pressure-sensitive adhesive layer further contains a fatty acid monoglyceride as a percutaneous penetration enhancer.

5. The percutaneous absorption preparation of claim 2, wherein the pressure-sensitive adhesive layer further contains a percutaneous penetration enhancer.

6. The percutaneous absorption preparation of claim 2, wherein the pressure-sensitive adhesive layer further contains a fatty acid monoglyceride as a percutaneous penetration enhancer.

7. A method for producing a percutaneous absorption preparation comprising a backing having formed on one side thereof a pressure-sensitive adhesive layer containing a drug for percutaneous absorption use, which comprises:

adding a crosslinking agent to a solution of an acrylic copolymer to effect crosslinking,

pulverizing the resulting solution to prepare a pressure-sensitive adhesive solution,

adding a drug for percutaneous absorption use and optionally a percutaneous penetration enhancer to the pressure-sensitive adhesive solution, and

coating the backing with the resulting pressure-sensitive adhesive solution to form a pressure-sensitive adhesive layer.