Percutaneous absorption preparation
First Claim
1. A percutaneous absorption preparation comprising a backing having formed on one side thereof a pressure-sensitive adhesive layer containing a drug for percutaneous absorption use,wherein the pressure-sensitive adhesive layer contains(A) an acrylic copolymer which is an acrylic pressure-sensitive adhesive and(B) crosslinked acrylic copolymer particles prepared from an acrylic pressure-sensitive adhesive, wherein the crosslinked particles have a size of from about 0.05 to about 20 microns and are present in an amount of from about 70 to about 400 parts by weight of the acrylic copolymer.
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Accused Products
Abstract
The present invention provides a percutaneous absorption preparation which has excellent pressure-sensitive adhesive characteristics and exerts excellent percutaneous absorption property. A crosslinking agent is added to a solution of an acrylic copolymer prepared by copolymerizing a (meth)acrylic acid alkyl ester with a functional monomer, and the acrylic copolymer is partially crosslinked. A composition containing the crosslinked acrylic copolymer is pulverized to prepare a pressure-sensitive adhesive solution comprised of the acrylic copolymer containing crosslinked acrylic copolymer particles. Thereafter, a drug for percutaneous absorption use, a percutaneous penetration enhancer are added to the pressure-sensitive adhesive solution, thereby producing the percutaneous absorption preparation.
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Citations
7 Claims
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1. A percutaneous absorption preparation comprising a backing having formed on one side thereof a pressure-sensitive adhesive layer containing a drug for percutaneous absorption use,
wherein the pressure-sensitive adhesive layer contains (A) an acrylic copolymer which is an acrylic pressure-sensitive adhesive and (B) crosslinked acrylic copolymer particles prepared from an acrylic pressure-sensitive adhesive, wherein the crosslinked particles have a size of from about 0.05 to about 20 microns and are present in an amount of from about 70 to about 400 parts by weight of the acrylic copolymer.
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7. A method for producing a percutaneous absorption preparation comprising a backing having formed on one side thereof a pressure-sensitive adhesive layer containing a drug for percutaneous absorption use, which comprises:
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adding a crosslinking agent to a solution of an acrylic copolymer to effect crosslinking, pulverizing the resulting solution to prepare a pressure-sensitive adhesive solution, adding a drug for percutaneous absorption use and optionally a percutaneous penetration enhancer to the pressure-sensitive adhesive solution, and coating the backing with the resulting pressure-sensitive adhesive solution to form a pressure-sensitive adhesive layer.
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Specification