Seamless capsule and method of manufacturing the same

• US 5,882,680 A
• Filed: 12/03/1996
• Issued: 03/16/1999
• Est. Priority Date: 12/07/1995
• Status: Expired due to Term

• Current Assignee: Freund Industrial Company Limited
• Original Assignee: Freund Industrial Company Limited
• Inventors: Sugiyama, Mamoru, Suzuki, Toshiyuki, Ikeda, Masayuki
• Primary Examiner(s): Wu, David W.
• Application Number:
  US08/757,135
• Time in Patent Office: 833 Days
• Field of Search: 424/451, 424/452, 424/456, 424/457, 424/458
• US Class Current: 424/451
• CPC Class Codes: A61K 9/14 Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles microspheres A61K9/16; microcapsules A61K9/50; nanocapsules, nanoparticles of the matrix type A61K9/51
• CPC Class Codes: A61K 9/4833 Encapsulating processes; Filling of capsules mechanical aspects A61J3/07
• CPC Class Codes: A61K 9/5089 Processes
• CPC Class Codes: B01J 13/04 by physical processes, e.g. drying, spraying

Abstract

There are provided a seamless capsule containing therein a large quantity of an active ingredient which is difficultly soluble in water and oil and a method of manufacturing the seamless capsule. Encapsulating liquid 1, in which the active ingredient is difficultly soluble in water and oil is suspended in oil as particles each having the mean particle diameter of less than 20 μm, is enclosed in hydrophilic outer shells. This seamless capsule SC is manufactured in such a manner that from a multiple nozzle 7, suspension, in which the active ingredient which is difficultly soluble in water and oil is dispersed in oil and the active ingredient in thus obtained dispersion is pulverized to obtain particles each having the mean particle diameter of less than 20 μm, as encapsulating liquid 1, and aqueous liquid of a shell forming substance, as outer shell forming liquid 3, are dropped into hardening liquid 10.

Claims

1. A seamless capsule, wherein liquid, in which an active ingredient is suspended in oil as particles each having a mean particle diameter of less than 20 μ

m, is encapsulated in a hydrophilic outer shell, said active ingredient having a solubility in water and oil of less than 10 g/100 ml.

2. A seamless capsule as set forth in claim 1, wherein said particles are formed by wet-pulverizing said active ingredient in oil.

3. A seamless capsule as set forth in claim 1, wherein said active ingredient is contained in said outer shell as particles each having the mean particle diameter of less than 20 μ

m.

4. A seamless capsule as set forth in claim 3, wherein the particles of said outer shell are formed by wet-pulverizing said active ingredient in water.

5. A seamless capsule as set forth in claim 2, wherein said active ingredient is contained in said outer shell as particles each having the mean particle diameter of less than 20 μ

m.