Oligonucleotide inhibition of protein kinase C
First Claim
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1. An antisense oligonucleotide up to 50 nucleotide units in length comprising SEQ ID NO:
- 2, which oligonucleotide specifically binds human protein kinase C-α
mRNA.
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Abstract
Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. In preferred embodiments, the oligonucleotides contain one or more chemical modifications. Methods of modulating PKC expression and of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C expression using oligonucleotides targeted to PKC are disclosed.
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7 Claims
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1. An antisense oligonucleotide up to 50 nucleotide units in length comprising SEQ ID NO:
- 2, which oligonucleotide specifically binds human protein kinase C-α
mRNA. - View Dependent Claims (2, 3, 4, 5, 6, 7)
- 2, which oligonucleotide specifically binds human protein kinase C-α
Specification