2-Substituted vitamin D derivatives

• US 5,883,271 A
• Filed: 10/08/1997
• Issued: 03/16/1999
• Est. Priority Date: 01/23/1995
• Status: Expired due to Fees

• Current Assignee: Chugai Seiyaku Kabushiki Kaisha (Roche Holding AG)
• Original Assignee: Chugai Seiyaku Kabushiki Kaisha (Roche Holding AG)
• Inventors: Ono, Yoshiyuki
• Primary Examiner(s): Dees, Jose' G.
• Assistant Examiner(s): PRYOR, ALTON NATHANIEL
• Application Number:
  US08/875,292
• Time in Patent Office: 524 Days
• Field of Search: 552/563, 514/167
• US Class Current: 552/653
• CPC Class Codes: C07C 401/00 Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
• CPC Class Codes: C07J 51/00 Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
• CPC Class Codes: C07J 71/001 Oxiranes
• CPC Class Codes: C07J 9/00 Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
• CPC Class Codes: C07J 9/005 containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Abstract

A compound represented by general formula (I): ##STR1## wherein R₁ and R₂, each presents an ethyl group and R₃ represents an alkoxy group having (1) to (7) carbon atoms which may be substituted by one or more substituents selected from a hydroxyl group, a halogen atom, a cyano group, an alkoxy group having (1) to (4) carbon atoms, an amino group and an acylamino group with the proviso that R₁ and R₂ are not a methyl group simultaneously, is disclosed.

The compound according to the present invention is useful as a pharmaceutical.

Claims

1. A compound represented by general formula (I):

##STR17## wherein R₁ and R₂, each represents an ethyl group and R₃ represents an alkoxy group having 1 to 7 carbon atoms which may be substituted by one or more substituents selected from a hydroxyl group, a halogen atom, a cyano group, an alkoxy group having 1 to 4 carbon atoms, an amino group and an acylamino group with the proviso that R₁ and R₂ are not a methyl group simultaneously.

2. The compound according to claim 1 wherein R₃ is an alkoxy group having 1 to 7 carbon atoms which may be unsubstituted or substituted by one or more hydroxyl groups.

3. The compound according to claim 2 wherein R₃ is an alkoxy group having 1 to 7 carbon atoms which is substituted by one or more hydroxyl groups.

4. The compound according to claim 1 which is represented by general formula (II):

##STR18## wherein R₁ and R₂, each represents an ethyl group and R₃ represents an alkoxy group which may be substituted by one or more substituents selected from a hydroxyl group, a halogen atom, a cyano group, an alkoxy group having 1 to 4 carbon atoms, an amino group and an acylamino group with the proviso that R₁ and R₂ are not a methyl group simultaneously.

5. The compound according to claim 4 wherein R₃ is an alkoxy group having 1 to 7 carbon atoms which may be unsubstituted or substituted by one or more hydroxyl groups.

6. The compound according to claim 5 wherein R₃ is an alkoxy group having 1 to 7 carbon atoms which is substituted by one or more hydroxyl groups.

7. The compound according to claim 6 which is represented by general formula (III):

##STR19##