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Controlled fluid transport in microfabricated polymeric substrates

  • US 5,885,470 A
  • Filed: 04/14/1997
  • Issued: 03/23/1999
  • Est. Priority Date: 04/14/1997
  • Status: Expired due to Term
First Claim
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1. A microfluidic system, comprising:

  • a microfluidic device which comprises a body substantially fabricated from a polymeric material, said body having at least first and second intersecting channels disposed therein, interior surfaces of said at least first and second intersecting channels having a zeta potential associated therewith, which zeta potential is capable of supporting an electroosmotic mobility of a fluid in said channels of at least 1×

    10-5 cm2 V-1 s-1, wherein said fluid is a sodium borate buffer having an ionic strength of between about 1 and about 10 mM, and a pH of from about 7 to about 9, at least one of said at least first and second intersecting channels having at least one cross sectional dimension in the range of from about 0.1 μ

    m to about 500 μ

    m;

    at least first, second and third ports disposed at termini of said first channel and at least one terminus of said second channel, whereby said ports are in electrical contact with a fluid in said first and second channels; and

    an electrical control system for concomitantly applying a voltage at at least two of said at least first, second and third ports, to selectively direct flow of a fluid in said first and second intersecting channels by electroosmotic flow.

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