Biocompatible articles and method for making same
First Claim
1. An article of manufacture that is resistant to plasma protein adsorption, platelet adhesion, and thrombus formation, said article comprising a cationic polymer matrix which has been surface-modified by a method comprising, in the order given, the steps of:
- a. swelling a cationic polymer matrix in a medium having a pH value <
7;
b. removing the swelled cationic polymer matrix from said medium;
c. applying a surface-modifying agent to an entire surface of said cationic polymer matrix to form a mixture; and
d. adjusting the pH of said mixture to a value ≧
7.
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Accused Products
Abstract
Articles of manufacture and methods of making the same, comprising a cationic polymer which has been surface-modified by a method comprising the steps of swelling a cationic polymer in a medium having a pH value <7; applying a surface-modifying agent to the cationic polymer to form a mixture; and adjusting the pH of the mixture to a value ≧7. A preferred embodiment relates to semipermeable membranes suitable for hemodialysis made from chitosan, the surface of which has been modified by anionic polysaccharides such as dextran or heparin, or anionic polyoxyalkylenes such as acid-modified polyethylene glycol, to improve blood compatibility.
65 Citations
18 Claims
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1. An article of manufacture that is resistant to plasma protein adsorption, platelet adhesion, and thrombus formation, said article comprising a cationic polymer matrix which has been surface-modified by a method comprising, in the order given, the steps of:
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a. swelling a cationic polymer matrix in a medium having a pH value <
7;b. removing the swelled cationic polymer matrix from said medium; c. applying a surface-modifying agent to an entire surface of said cationic polymer matrix to form a mixture; and d. adjusting the pH of said mixture to a value ≧
7. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 13, 14, 15)
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10. A method of preparing a biocompatible cationic polymer-containing article that is resistant to plasma protein adsorption, platelet adhesion, or thrombus formation, comprising, in the order given, the steps of:
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a. placing a cationic polymer matrix-containing article in a medium having a pH value <
7 and swelling said polymer matrix;b. removing the swelled cationic polymer matrix-containing article from said medium; c. applying a surface-modifying agent to an entire surface of said cationic polymer matrix-containing article to form a mixture; and d. adjusting the pH of said mixture to a value ≧
7. - View Dependent Claims (16, 17, 18)
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Specification