Methods useful for the treatment of neurological and mental disorders related to deficient serotonin neurotransmission and impaired pineal melatonin functions

• US 5,885,976 A
• Filed: 11/25/1997
• Issued: 03/23/1999
• Est. Priority Date: 05/08/1995
• Status: Expired due to Fees

• Current Assignee: Reuven Sandyk
• Original Assignee: Reuven Sandyk
• Inventors: Sandyk, Reuven
• Primary Examiner(s): Raymond, Richard L.
• Application Number:
  US08/978,383
• Time in Patent Office: 483 Days
• Field of Search: 514/159, 514/160, 514/250, 514/355, 514/345, 514/419, 514/654, 514/657
• US Class Current: 514/159
• CPC Class Codes: A61N 2/002 in combination with another treatment
• CPC Class Codes: A61N 2/006 for magnetic stimulation of nerve tissue

Abstract

A composition is described which is useful for treating neurological and mental disorders which are associated with and/or related pathogenetically to deficient serotonin neurotransmission and impaired pineal melatonin functions in humans the composition being administered in combination with a sufficient amount of an AC pulsed magnetic field alone or in conjunction with a DC magnetic field and a sufficient amount of random noise to the brain of a human in need of such treatment which composition comprises an effective amount of a composition which increases serotonin transmission to the human to be treated. A method of treating neurological and mental disorders which are associated with and/or related pathogenetically to deficient serotonin neurotransmission and impaired pineal melatonin functions in humans is described which comprises administering to a human in need thereof an effective amount of a composition which increases serotonin transmission to the human to be treated followed by the application to the brain of the human of a sufficient amount of AC pulsed magnetic field alone, or in combination with a DC magnetic field and low frequency random noise, of proper intensity, frequency, waveform, wave symmetry and phase shift of the wave to treat the disorder.

Claims

1. A method of treating neurological and mental disorders which are associated with and related pathogenetically to deficient serotonin transmission and impaired pineal melatonin functions in humans and for treating neurological and mental disorders which are associated with or related pathogenetically to deficient serotonin neurotransmission and impaired pineal melatonin functions in humans which comprises administering to a human in need thereof an effective amount of a composition which increases serotonin transmission to the human to be treated followed by the application to the brain of the human of a sufficient amount of an AC pulsed magnetic field alone, or in combination with a DC magnetic field and low frequency random noise, of proper intensity, frequency, waveform, wave symmetry and phase shift of the wave to treat the disorder.

2. A method according to claim 1 which further comprises having the human consume a sufficient amount of a dietary composition which will increase plasma tryptophan concentrations beginning prior to the application of the magnetic field.

3. A method according to claim 1 for the treatment of juvenile Parkisnonism wherein the AC pulsed frequency is 5-Hz-8.5 Hz.

4. A method according to claim 1 for the treatment of progressive supranuclear palsy wherein the AC pulsed frequency is 5 Hz-8 Hz.

5. A method according to claim 1 for the treatment of motor neuron disease (amyotrophic lateral sclerosis) wherein the AC pulsed frequency is 5 Hz-8 Hz.

6. A method according to claim 1 for the treatment of essential tremor wherein the AC pulsed frequency is 5 Hz-8 Hz.

7. A method according to claim 1 for the treatment of Huntington'"'"'s chorea wherein the AC pulsed frequency is 5 Hz-8 Hz.

8. A method according to claim 1 for the treatment of AIDS dementia wherein the AC pulsed frequency is 5 Hz-8 Hz.

9. A method according to claim 1 for the treatment of Shy-Drager syndrome wherein the AC pulsed frequency is 5 Hz-8 Hz.

10. A method according to claim 1 for the treatment of traumatic spinal cord injuries wherein the AC pulsed frequency is 3 Hz-7 Hz.

11. A method according to claim 1 for the treatment of ischemic stroke wherein the AC pulsed frequency is 5 Hz-8 Hz.

12. A method according to claim 1 for the treatment of autism wherein the AC pulsed frequency is 3 Hz-7 Hz.

13. A method according to claim 1 for the treatment of macular degeneration wherein the AC pulsed frequency is 5 Hz-7 Hz.

14. A method according to claim 1 for the treatment of diabetic neuropathy wherein the AC pulsed frequency is 5 Hz-7 Hz.

15. A method according to claim 1 for the treatment of alcohol dependency wherein the AC pulsed frequency is 5 Hz-7 Hz.

16. A method according to claim 1 for the treatment of trichotillomania wherein the AC pulsed frequency is 5 Hz-7 Hz.

17. A method according to claim 1 for the treatment of posttraumatic stress disorder wherein the AC pulsed frequency is 5 Hz-8 Hz.

18. A method according to claim 1 for the treatment of impulsive aggressive behavior wherein the AC pulsed frequency is 5 Hz-8 Hz.

19. A method according to claim 1 for the treatment of chronic insomnia wherein the AC pulsed frequency is 5 Hz-8 Hz.

20. A method according to claim 1 for the treatment of sleep paralysis wherein the AC pulsed frequency is 5 Hz-7 Hz.

21. A method according to claim 1 for the treatment of bulimia wherein the AC pulsed frequency is 5 Hz-8 Hz.

22. A method according to claim 1 for the treatment of multiple sclerosis wherein the amplitude of the AC pulsed magnetic field is modulated at a range of 25%-100%.

23. A method according to claim 1 for the treatment of multiple sclerosis wherein the frequency of the AC pulsed magnetic field is modulated at a range of 10%-50%.

24. A method according to claim 1 for the treatment of multiple sclerosis wherein the shape of the waveform of the AC pulsed magnetic field is symmetric or asymmetric.

25. A method according to claim 1 for the treatment of multiple sclerosis wherein the AC pulsed magnetic field is combined with a DC magnetic field.

26. A method according to claim 1 for the treatment of multiple sclerosis wherein random noise of proper frequency is combined with the AC pulsed magnetic field.

27. A method according to claim 1 for the treatment of multiple sclerosis wherein the magnetic field is administered over the temples in a form of a two-phase AC pulsed sinusoidal wave with a phase shift ranging from 0°

to 180°

.

28. A method according to claim 1 for the treatment of multiple sclerosis wherein the AC pulsed magnetic field is applied simultaneously over both temples or alternating from side to side at an interval of 5 to 30 seconds.

29. A method according to claim 1 for the treatment of juvenile Parkinsonism wherein the AC pulsed magnetic field is a time varying field with a waveform which is square.

30. A method according to claim 1 for the treatment of Gilles de la Tourette'"'"'s syndrome wherein the AC pulsed magnetic field is combined with random noise of proper frequency.

31. A method according to claim 1 wherein the stimulant of serotonin receptors is ergoloid mesylates, pergolide mesylate, or buspirone.

32. A method according to claim 1 wherein the composition includes a stimulant of serotonin synthesis which is vitamin B1, vitamin B3, vitamin B6, blotin, S-adenosyl methionine, vitamin D, folic acid, ascorbic acid, magnesium, coenzyme Q₁₀, piracetam, or mixtures of two or more thereof.

33. A method according to claim 1 wherein the composition includes the serotonin re-uptake inhibitor which is sertraline, nefazodone, trazodone, fluoxetine or a mixture thereof.

34. A method according to claim 2 wherein the dietary composition comprises tryptophan rich foods.

35. A method according to claim 34 wherein the tryptophan rich foods are turkey, milk, bananas, nuts, and sunflower seeds.

36. A method according to claim 35 for the treatment of motor neuron disease, autism, alcohol dependency and posttraumatic stress syndrome wherein 4 oz. of turkey twice a week, 8 oz. of milk per day, 1 banana per day, 1-2 oz. of nuts per day and 3-4 oz. of sunflower seeds per day consumed by the human.

37. A method according to claim 1 wherein the AC pulsed magnetic fields are applied to the brain of the human using a helmet-like transducer array.

38. A method according to claim 37 wherein the helmet-like transducer array comprises an array of coils which are flat or helical.

39. A method according to claim 1 wherein the AC pulsed magnetic fields are applied to the brain of the human through a transducer embedded in an earphone-like headset.

40. A method according to claim 39 wherein the transducer is comprised of 3 solenoid-like coils which are connected in parallel.

41. A method according to claim 40 wherein the AC pulsed magnetic fields are applied to the brain over the temples.

42. A method according to claim 41 wherein the strength of the AC pulsed magnetic field is in the range of 7.5 picotesia to 1 microtesia flux density.

43. A method according to claim 1 wherein the AC pulsed magnetic field is a time varying field with a waveform which is sinusoidal, triangular, trapezoidal, square, sawtooth or a composite thereof, dependent upon the condition to be treated.

44. A method according to claim 1 wherein the composition which increases serotonin transmission comprises an effective amount of a serotonin precursor, an effective amount of a stimulant to increase plasma tryptophan concentrations, an effective amount of a stimulant to facilitate the transport of tryptophan into the brain of the human, an effective amount of a stimulant of serotonin synthesis, an effective amount of a serotonin reuptake inhibitor, an effective amount of a stimulant of serotonin release and an effective amount of a stimulant of serotonin receptors.

45. A method according to claim 43 wherein the serotonin precursor is selected from the group consisting of L-tryptophon or L-5-hydroxytryptophan;

the stimulant to increase plasma tryptophan concentrations is a salicylate;

the stimulant to facilitate the transport of tryptophon into the brain is selected from the group consisting of vitamin B3 and chromium;

the stimulant of serotonin synthesis is selected from the group consisting of vitamin B1, vitamin B3, vitamin B6, biotin, S-adenosylmethionine, vitamin D, folic acid, ascorbic acid, magnesium, coenzyme Q10 and piracetam;

the serotonin reuptake inhibitor is selected from the group consisting of sertraline, nefazodone, fluoxetine and trazodone;

the stimulant of serotonin release is fenfluramine; and

the stimulant of serotonin receptor is selected from the group consisting of ergolold mesylate, pergolide mesylate, and buspirone.