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Triterpene derivative and medicinal composition

  • US 5,885,992 A
  • Filed: 12/19/1996
  • Issued: 03/23/1999
  • Est. Priority Date: 06/24/1994
  • Status: Expired due to Fees
First Claim
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1. A method for treating an animal suffering from nephritis, which comprises administering to the sufferer an effective amount of a compound of formula (1) or a pharmaceutically acceptable salt thereof, or a solvate of said compound or said salt:

  • ##STR13## wherein R1 is OR11 or NR11 R12, R11 and R12 are the same or different and each is (1) hydrogen, (2) alkyl optionally substituted, (3) cycloalkyl optionally substituted, (4) alkenyl optionally substituted, (5) alkynyl optionally substituted, (6) aryl optionally substituted, or (7) a heteroaromatic group optionally substituted;

    R2 and R3 is the same or different and each is (1) hydrogen, (2) alkyl optionally substituted, (3) cycloalkyl optionally substituted, (4) alkenyl optionally substituted, (5) alkynyl optionally substituted, (6) acyl optionally substituted, (7) monoalkylcarbamoyl optionally substituted, (8) dialkylcarbamoyl optionally substituted, or (9) alkoxy carbonyl optionally substituted, or R2 and R3 taken together is carbonyl;

    wherein the substituents on R11, R12, R2, R3 are the same or different and are selected from (1) halogen, (2) OR13, (3) OCOR13, (4) COOR13, (5) cyano, (6) NR13 R14, (7) cycloalkyl, (8) aryl optionally substituted by halogen, alkyl, hydroxy, or amino, and (9) a heteroaromatic group optionally substituted by halogen, alkyl, hydroxy, or amino;

    wherein R13 and R14 are the same or different and each is (1) hydrogen or (2) alkyl optionally substituted by hydroxy, alkoxy, amino, monoalkylamino, or dialkylamino.

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