Method of treatment for disease associated with excessive PHF using combination therapy involving exogenous calcium and calcium channel blockers

• US 5,886,012 A
• Filed: 04/09/1997
• Issued: 03/23/1999
• Est. Priority Date: 03/22/1989
• Status: Expired due to Fees

• Current Assignee: Peter K.T. Pang
• Original Assignee: Peter K.T. Pang
• Inventors: Pang, Peter K. T., Benishin, Christine G., Shan, Jie, Lewanczuk, Richard Z.
• Primary Examiner(s): Criares, Theodore J.
• Application Number:
  US08/833,779
• Time in Patent Office: 713 Days
• Field of Search: 514/354, 514/355, 514/356
• US Class Current: 514/356
• CPC Class Codes: A61K 31/4422 1,4-Dihydropyridines, e.g. nifedipine, nicardipine

Abstract

Hypotensive mammals are treated to lower mean blood pressure by administering synergistic amounts of a calcium blocking agent together with a calcium supplement.

Claims

1. A method of treating non-insulin dependent diabetes mellitus in a patient in need thereof, comprising coadministering to the patient

(a) a dihydropyridine calcium channel blocking agent;

and

(b) a calcium supplement,

wherein the ratio by weight of elemental calcium to dihydropyridine calcium channel blocking agent is at least 40;

1, and the dihydropyridine calcium channel blocking agent and the calcium supplement are present in respective amounts whereby, in combination, they are synergistically effective in treating the non-insulin dependent diabetes mellitus in the patient.

2. The method of claim 1, wherein the dihydropyridine calcium channel blocking agent is nifedipine.

3. The method of claim 1, wherein the calcium supplement is calcium carbonate.